Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | CCR1 | P32246 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | KLKB1 | P03952 | 4/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15473395 | 0.83 | LRRK2 (0.45) | GAALRRK2TP53L3MBTL1 | |
| SCHEMBL6989663 | 0.79 | LRRK2 (0.36) | GAALRRK2L3MBTL1KLKB1NPC1 | |
| SCHEMBL14996622 | 0.78 | GAA (0.31) | GAA | |
| SCHEMBL31741753 | 0.78 | DGAT1 (0.42) | GAAKLKB1 | |
| SCHEMBL28740668 | 0.77 | GAA (0.44) | GAAKLKB1NPC1PKM | |
| SCHEMBL12126144 | 0.77 | L3MBTL1 (0.33) | L3MBTL1 | |
| SCHEMBL23174789 | 0.76 | LMNA (0.43) | GAACCR1NPC1PKM | |
| SCHEMBL12121226 | 0.75 | P2RX7 (0.40) | GAALRRK2 | |
| SCHEMBL15684076 | 0.74 | GAA (0.32) | GAA | |
| SCHEMBL29796452 | 0.74 | GAA (0.32) | GAAKLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8183416-B2 | Heterocyclic amide derivatives useful as microbiocides | SYNGENTA CROP PROTECTION, INC. (US) | 2012-05-22 | — | — | US | disclosed |
| US-7994093-B2 | Heterocyclocarboxamide derivatives | SYNGENTA CROP PROTECTION, INC. (US) | 2011-08-09 | — | — | US | disclosed |
| US-7994093-B2 | Heterocyclocarboxamide derivatives | SYNGENTA CROP PROTECTION, INC. (US) | 2011-08-09 | — | — | US | disclosed |
| EP-1940813-B1 | HETEROCYCLIC AMIDE DERIVATIVES USEFUL AS MICROBIOCIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2010-11-24 | — | — | EP | disclosed |
| US-20100204482-A1 | HETEROCYCLIC AMIDE DERIVATIVES USEFUL AS MICROBIOCIDES | SYNGENTA CROP PROTECTION, INC. (US) | 2010-08-12 | — | — | US | disclosed |
| US-7732469-B2 | for controlling or preventing infestation of plants by phytopathogenic microorganisms, preferably fungi | SYNGENTA CROP PROTECTION, INC. (US) | 2010-06-08 | — | — | US | disclosed |
| US-20100010063-A1 | HETEROCYCLOCARBOXAMIDE DERIVATIVES | SYNGENTA CROP PROTECTION, INC. (US) | 2010-01-14 | — | — | US | disclosed |
| US-20100010063-A1 | HETEROCYCLOCARBOXAMIDE DERIVATIVES | SYNGENTA CROP PROTECTION, INC. (US) | 2010-01-14 | — | — | US | disclosed |
| US-7598395-B2 | Tricyclic amine derivatives such as 3-Difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid (9-isopropyl-1,2,3,4-tetrahydro-1,4-methano-naphthalen-5-yl)-amide; fungicides; horticulture | SYNGENTA CROP PROTECTION, INC. (US) | 2009-10-06 | — | — | US | disclosed |
| US-20080227835-A1 | Heterocyclic Amide Derivatives Useful as Microbiocides | SYNGENTA CROP PROTECTION, INC. (US) | 2008-09-18 | — | — | US | disclosed |
| US-20080051446-A1 | Heterocyclocarboxamide Derivatives | SYNGENTA CROP PROTECTION, INC. | 2008-02-28 | — | — | US | disclosed |
| WO-2007124907-A2 | HETEROCYCLYL-CARBOXYLIC ACID (BENZONORBORNENE-5-YL)AMIDE DERIVATIVES AS FUNGICIDES FOR AGROCHEMICAL USE | SYNGENTA PARTICIPATIONS AG (CH) | 2007-11-08 | — | — | WO | disclosed |
| WO-2007048556-A1 | HETEROCYCLIC AMIDE DERIVATIVES USEFUL AS MICROBIOCIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2007-05-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100010063-A1 | HETEROCYCLOCARBOXAMIDE DERIVATIVES | CBR3, CBR1, NOX1 | GAA 3577/4885LRRK2 2808/4885CCR1 743/4885 |
| US-20100204482-A1 | HETEROCYCLIC AMIDE DERIVATIVES USEFUL AS MICROBIOCIDES | CBR3, CBR1, CYP8B1 | GAA 3293/4885LRRK2 4380/4885CCR1 203/4885 |
| US-20080051446-A1 | Heterocyclocarboxamide Derivatives | CBR3, CBR1, NOX1 | GAA 3577/4885LRRK2 2808/4885CCR1 743/4885 |
| US-20080227835-A1 | Heterocyclic Amide Derivatives Useful as Microbiocides | CBR3, CBR1, CYP8B1 | GAA 3373/4885LRRK2 4185/4885CCR1 220/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.