Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.39 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.39 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | RIOK2 | Q9BVS4 | 1/20 | 0.37 |
| ▸ | PROKR1 | Q8TCW9 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6989808 | 0.92 | KDM4C (0.48) | NPC1RAB9ASMN1; SMN2PKMLMNA | |
| SCHEMBL6990533 | 0.74 | SLC2A1 (0.53) | MAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL6990114 | 0.72 | LPAR1 (0.49) | SMN1; SMN2HPGDLMNAKMT2AMEN1 | |
| SCHEMBL27071638 | 0.72 | CCR1 (0.44) | NPC1RAB9ALMNAMAPTRIOK2 | |
| SCHEMBL5213278 | 0.71 | ALDH1A1 (0.56) | NPC1RAB9ASMN1; SMN2PKMCDK5 | |
| SCHEMBL19632157 | 0.68 | KDM4C (0.57) | NPC1RAB9ASMN1; SMN2PKMCDK5 | |
| SCHEMBL6990109 | 0.68 | LPAR1 (0.53) | NPC1RAB9ASMN1; SMN2PKMMAPT | |
| SCHEMBL19615626 | 0.67 | CA1 (0.57) | NPC1RAB9ASMN1; SMN2PKMCDK5 | |
| SCHEMBL6988718 | 0.67 | RAB9A (0.41) | NPC1RAB9ASMN1; SMN2PKMCYP1A2 | |
| SCHEMBL6990355 | 0.66 | SLC2A1 (0.61) | SMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1362033-A1 | PYRIDINE MATRIX METALLOPROTEINASE INHIBITORS | Warner-Lambert Company LLC (US) | 2003-11-19 | — | — | EP | claimed |
| WO-2002064568-A1 | PYRIDINE MATRIX METALLOPROTEINASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2002-08-22 | — | — | WO | claimed |