Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | APAF1 | O14727 | 1/20 | 0.40 |
| ▸ | NSD2 | O96028 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6988711 | 0.92 | CA12 (0.51) | RAB9AKDM4ESMN1; SMN2NPC1TSHR | |
| SCHEMBL6986939 | 0.76 | KMT2A (0.48) | RAB9AKDM4ESMN1; SMN2NPC1L3MBTL1 | |
| SCHEMBL6993032 | 0.74 | KMT2A (0.49) | KDM4ESMN1; SMN2CYP1A2CYP3A4ELANE | |
| SCHEMBL6993029 | 0.69 | ALDH1A1 (0.48) | KDM4ESMN1; SMN2CYP1A2CYP3A4TSHR | |
| SCHEMBL2932540 | 0.69 | CYP1A1 (0.48) | RAB9AKDM4ESMN1; SMN2CYP1A2CYP3A4 | |
| SCHEMBL6986935 | 0.68 | KDM5A (0.49) | RAB9AKDM4ESMN1; SMN2NPC1MAPT | |
| SCHEMBL1949545 | 0.68 | TSHR (0.47) | KDM4ESMN1; SMN2CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL6988723 | 0.68 | SMN1; SMN2 (0.47) | KDM4ESMN1; SMN2NPC1CYP1A2CYP3A4 | |
| SCHEMBL5214366 | 0.68 | NPC1 (0.71) | RAB9AKDM4ESMN1; SMN2NPC1CYP1A2 | |
| SCHEMBL6989809 | 0.67 | NPC1 (0.39) | RAB9AKDM4ESMN1; SMN2NPC1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1362033-A1 | PYRIDINE MATRIX METALLOPROTEINASE INHIBITORS | Warner-Lambert Company LLC (US) | 2003-11-19 | — | — | EP | claimed |
| WO-2002064568-A1 | PYRIDINE MATRIX METALLOPROTEINASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2002-08-22 | — | — | WO | claimed |