Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 11/20 | 0.57 |
| ▸ | DRD2 | P14416 | 11/20 | 0.57 |
| ▸ | DRD1 | P21728 | 2/20 | 0.57 |
| ▸ | DRD4 | P21917 | 5/20 | 0.55 |
| ▸ | HTR7 | P34969 | 5/20 | 0.53 |
| ▸ | HTR1A | P08908 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.53 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.53 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6989466 | 0.87 | HTR1A (0.59) | DRD3DRD2DRD1DRD4HTR7 | |
| SCHEMBL6984158 | 0.86 | HTR1A (0.60) | DRD3DRD2DRD1DRD4HTR7 | |
| SCHEMBL6988196 | 0.85 | HTR1A (0.50) | DRD3DRD2HTR7HTR1AHTR6 | |
| SCHEMBL6991218 | 0.85 | HTR1A (0.50) | DRD3DRD2HTR7HTR1AHTR6 | |
| SCHEMBL6984315 | 0.84 | HTR1A (0.49) | DRD3DRD2DRD4HTR7HTR1A | |
| SCHEMBL6990381 | 0.82 | HTR1A (0.49) | DRD3DRD2DRD4HTR7HTR1A | |
| SCHEMBL6990417 | 0.81 | DRD3 (0.67) | DRD3DRD2DRD1DRD4HTR7 | |
| SCHEMBL6990656 | 0.79 | ADRA1D (0.47) | DRD3DRD2DRD4HTR7HTR1A | |
| SCHEMBL6987269 | 0.78 | L3MBTL1 (0.38) | HTR7HTR1AMEN1KMT2A | |
| SCHEMBL6986608 | 0.78 | L3MBTL1 (0.38) | HTR7HTR1AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0551527-B1 | PYRROLOAZEPINE DERIVATIVE | SUNTORY LTD (JP) | 2003-04-02 | — | — | EP | disclosed |
| US-5397780-A | Antiserotonine, hypotensive, congestive heart failure | SUNTORY LIMITED (JP) | 1995-03-14 | — | — | US | disclosed |
| EP-0551527-A1 | PYRROLOAZEPINE DERIVATIVE | SUNTORY LIMITED (JP) | 1993-07-21 | — | — | EP | disclosed |