Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | PYGL | P06737 | 2/20 | 0.46 |
| ▸ | NHERF1 | O14745 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.45 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7833259 | 0.80 | MMP13 (0.58) | MMP13LMNAHPGDSMN1; SMN2ROCK2 | |
| SCHEMBL6826452 | 0.78 | LOXL2 (0.64) | LMNAPYGLNHERF1SMN1; SMN2SIRT1 | |
| SCHEMBL6993438 | 0.78 | SMN1; SMN2 (0.52) | LMNAHPGDSMN1; SMN2SIRT1NPC1 | |
| SCHEMBL6987109 | 0.76 | F2 (0.54) | NHERF1SMN1; SMN2SIRT1ALDH1A1 | |
| SCHEMBL6994727 | 0.76 | LOXL2 (0.57) | HPGDSMN1; SMN2SIRT1NPC1ALDH1A1 | |
| SCHEMBL9530334 | 0.76 | MEN1 (0.49) | SMN1; SMN2SIRT1KMT2AMAPTMEN1 | |
| SCHEMBL12096730 | 0.74 | SIRT1 (0.56) | PYGLNHERF1SMN1; SMN2SIRT1NPC1 | |
| SCHEMBL6984195 | 0.73 | LOXL2 (0.49) | SMN1; SMN2SIRT1MAPT | |
| SCHEMBL6989926 | 0.73 | LOXL2 (0.49) | SMN1; SMN2SIRT1 | |
| SCHEMBL6015700 | 0.72 | MAOB (0.67) | MMP13LMNAHPGDSMN1; SMN2ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1322646-A1 | 2-(1H-INDOL-3-YL)-2-OXO-ACETIC ACID AMIDES WITH ANTITUMOR ACTIVITY | Novuspharma S.p.A. (IT) | 2003-07-02 | — | — | EP | disclosed |
| WO-2002008225-A1 | 2-(1H-INDOL-3-YL)-2-OXO-ACETIC ACID AMIDES WITH ANTITUMOR ACTIVITY | NOVUSPHARMA S.P.A. (IT) | 2002-01-31 | — | — | WO | disclosed |