Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 3/20 | 0.49 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.38 |
| ▸ | KDM5A | P29375 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18477010 | 0.77 | LOXL2 (0.53) | KIF11KDM4EALDH1A1HPGDKDM5A | |
| SCHEMBL19360375 | 0.74 | KDM4E (0.46) | KIF11KDM4EALDH1A1LMNAHTT | |
| SCHEMBL18440586 | 0.73 | SRD5A2 (0.55) | SMN1; SMN2SLC6A2KDM5AKDM4CKDM5B | |
| SCHEMBL6992353 | 0.73 | LOXL2 (0.49) | KIF11KDM5AKDM4CKDM5B | |
| SCHEMBL12096643 | 0.72 | KLKB1 (0.44) | KIF11KDM4EALDH1A1LMNAHTT | |
| SCHEMBL9370958 | 0.72 | MMP2 (0.56) | MMP2MMP13ALDH1A1SMN1; SMN2 | |
| SCHEMBL9371502 | 0.72 | MMP2 (0.53) | MMP2MMP13KDM4EALDH1A1LMNA | |
| SCHEMBL17027129 | 0.72 | F2 (0.55) | KIF11SMN1; SMN2KDM5AKDM4CKDM5B | |
| SCHEMBL13656086 | 0.72 | KIF11 (0.89) | KIF11KDM4EALDH1A1LMNAHPGD | |
| SCHEMBL9371043 | 0.71 | MMP2 (0.52) | MMP2MMP13KDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1322646-A1 | 2-(1H-INDOL-3-YL)-2-OXO-ACETIC ACID AMIDES WITH ANTITUMOR ACTIVITY | Novuspharma S.p.A. (IT) | 2003-07-02 | — | — | EP | disclosed |
| WO-2002008225-A1 | 2-(1H-INDOL-3-YL)-2-OXO-ACETIC ACID AMIDES WITH ANTITUMOR ACTIVITY | NOVUSPHARMA S.P.A. (IT) | 2002-01-31 | — | — | WO | disclosed |