Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 1/20 | 0.56 |
| ▸ | MMP13 | P45452 | 1/20 | 0.56 |
| ▸ | VCP | P55072 | 2/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 7/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | SPR | P35270 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9371502 | 0.84 | MMP2 (0.53) | MMP2MMP13VCPMTNR1AMTNR1B | |
| SCHEMBL9371043 | 0.83 | MMP2 (0.52) | MMP2MMP13VCPMTNR1AMTNR1B | |
| SCHEMBL8544817 | 0.81 | GAA (0.53) | FFAR1ALDH1A1 | |
| SCHEMBL9371052 | 0.79 | MMP2 (0.50) | MMP2MMP13VCPMTNR1AMTNR1B | |
| SCHEMBL28291608 | 0.79 | MMP2 (0.50) | MMP2MMP13VCPMTNR1AMTNR1B | |
| SCHEMBL8406457 | 0.78 | MMP13 (0.68) | MMP2MMP13ALDH1A1 | |
| SCHEMBL3052921 | 0.76 | LOXL2 (0.58) | FFAR1SMN1; SMN2PPARGFFAR4ALDH1A1 | |
| SCHEMBL12862876 | 0.75 | MMP13 (0.68) | MMP2MMP13SMN1; SMN2ALDH1A1 | |
| SCHEMBL9370964 | 0.74 | SPR (0.64) | MTNR1AMTNR1BSPRALDH1A1 | |
| SCHEMBL7476113 | 0.74 | MMP2 (0.59) | MMP2MMP13VCPSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0464558-B1 | Antimigraine alkoxypyrimidine derivatives | BRISTOL MYERS SQUIBB CO (US) | 1994-12-28 | — | — | EP | disclosed |
| EP-0464558-A1 | Antimigraine alkoxypyrimidine derivatives | Bristol-Myers Squibb Company (US) | 1992-01-08 | — | — | EP | disclosed |