Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.35 |
| ▸ | PPARD | Q03181 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.34 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.34 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.34 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6989037 | 0.83 | DDR1 (0.43) | CYP1A2CYP2C19LMNACYP3A4CYP2D6 | |
| SCHEMBL6990809 | 0.80 | MEN1 (0.48) | CYP1A2CYP2C19LMNACYP3A4CYP2D6 | |
| SCHEMBL6987229 | 0.79 | KCNJ11 (0.41) | MAPTEGFRERBB3NPC1RAB9A | |
| SCHEMBL6989465 | 0.79 | NPC1 (0.41) | GABRA5CYP1A2CYP2C19MAPTHTT | |
| SCHEMBL6981925 | 0.78 | NAMPT (0.50) | CYP1A2CYP2C19LMNACYP3A4MAPT | |
| SCHEMBL4367794 | 0.72 | GRM5 (0.45) | CYP1A2CYP2C19LMNACYP3A4CYP2D6 | |
| SCHEMBL6990458 | 0.72 | CSF1R (0.44) | LMNAMAPTMEN1KMT2ANPC1 | |
| SCHEMBL6986333 | 0.70 | MEN1 (0.48) | MAPTMEN1KMT2ANPC1RAB9A | |
| SCHEMBL1164021 | 0.70 | HDAC1 (0.47) | CYP1A2CYP2C19LMNACYP3A4CYP2D6 | |
| SCHEMBL6988688 | 0.70 | ABCC9 (0.41) | LMNANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358160-A1 | AMINAL DIONES AS POTASSIUM CHANNEL OPENERS | Abbott Laboratories (US) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002062761-A1 | AMINAL DIONES AS POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2002-08-15 | — | — | WO | disclosed |