SCHEMBL6990888

SCHEMBL6990888

CCCCN1C(=O)CSc2sc(C(=O)OC)cc21

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.46
CYP1A2 P05177 1/20 0.46
CYP2C19 P33261 1/20 0.46
SMN1; SMN2 Q16637 2/20 0.39
POLB P06746 2/20 0.39
L3MBTL1 Q9Y468 2/20 0.39
HPGD P15428 3/20 0.37
MAPT P10636 1/20 0.37
KDM4E B2RXH2 2/20 0.36
MAPK1 P28482 2/20 0.36
NPSR1 Q6W5P4 2/20 0.36
TSHR P16473 1/20 0.36
ATM Q13315 1/20 0.36
USP2 O75604 1/20 0.35
EGFR P00533 1/20 0.35
KDR P35968 1/20 0.35
KCNN4 O15554 2/20 0.35
NPC1 O15118 1/20 0.35
RAB9A P51151 1/20 0.35
CHRM2 P08172 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6996076 0.88 ALDH1A1 (0.41) ALDH1A1CYP1A2CYP2C19SMN1; SMN2POLB
SCHEMBL6992221 0.85 SMN1; SMN2 (0.39) ALDH1A1CYP1A2CYP2C19SMN1; SMN2POLB
SCHEMBL6989440 0.82 ALDH1A1 (0.50) ALDH1A1SMN1; SMN2POLBMAPTKDM4E
SCHEMBL31411882 0.81 LMNA (0.38) ALDH1A1CYP1A2SMN1; SMN2POLBL3MBTL1
Hydrochloric Acid SCHEMBL6995781 0.81 ALDH1A1 (0.34) ALDH1A1L3MBTL1EGFRKDRCHRM2
Hydrochloric Acid SCHEMBL6991139 0.81 KDM4E (0.37) ALDH1A1SMN1; SMN2POLBL3MBTL1HPGD
SCHEMBL6991944 0.79 KCNN4 (0.48) ALDH1A1CYP1A2CYP2C19SMN1; SMN2POLB
SCHEMBL6991542 0.79 PAX8 (0.59) ALDH1A1SMN1; SMN2POLBMAPTKDM4E
SCHEMBL6995107 0.78 ALDH1A1 (0.38) ALDH1A1CYP1A2SMN1; SMN2POLBHPGD
SCHEMBL7090950 0.77 ALDH1A1 (0.50) ALDH1A1CYP1A2CYP2C19SMN1; SMN2POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0927177-B1 NOVEL BENZOTHIOPHENE DERIVATIVES, THEIR PREPARATION AND USE AS UROKINASE INHIBITORS FUJISAWA PHARMACEUTICAL CO (JP) 2003-11-26 EP disclosed
US-6274619-B1 FUSED AMIDINO TYPE COMPOUNDS SUCH AS 4-(N-BUTYLCARBAMOYLMETHYLIDENE)-2-AMIDINO-4,5,6,7-TETRAHYDROBE NZO(B)THIOPHENE FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2001-08-14 US disclosed
US-6093710-A AN ENZYME INHIBITOR TREATING ANGIOGENESIS, ARTHRITIS, INFLAMMATION, METASTASIS, OSTEOPOROSIS, TUMORSANGIOGENESIS-DEPENDENT RETINOPATHIES, CONTRACEPTIVE FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2000-07-25 US disclosed