Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 4/20 | 0.48 |
| ▸ | HTR2A | P28223 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | HRH2 | P25021 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6989395 | 0.89 | HRH2 (0.47) | SIGMAR1DRD2HRH2HRH1KCNA5 | |
| SCHEMBL6989225 | 0.84 | ALDH1A1 (0.58) | KMT2AMEN1HRH2HRH1ALDH1A1 | |
| SCHEMBL9042911 | 0.84 | KCNH2 (0.55) | DRD2HTR2AKCNH2KDM4E | |
| SCHEMBL6988906 | 0.83 | HTR1A (0.47) | — | |
| SCHEMBL6986161 | 0.83 | HTR1A (0.53) | SIGMAR1DRD2HTR2AKCNH2DRD3 | |
| SCHEMBL6987477 | 0.82 | HRH2 (0.46) | KMT2AHRH2HRH1ALDH1A1TSHR | |
| SCHEMBL9266055 | 0.82 | HTR1A (0.54) | DRD2HTR2AKCNH2DRD3 | |
| SCHEMBL6988888 | 0.81 | DRD2 (0.57) | DRD2DRD3 | |
| SCHEMBL9038772 | 0.81 | KCNH2 (0.48) | DRD2HTR2AKCNH2ALDH1A1KDM4E | |
| SCHEMBL9039006 | 0.79 | SIGMAR1 (0.47) | SIGMAR1DRD2HTR2AKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0551527-B1 | PYRROLOAZEPINE DERIVATIVE | SUNTORY LTD (JP) | 2003-04-02 | — | — | EP | disclosed |
| US-5397780-A | Antiserotonine, hypotensive, congestive heart failure | SUNTORY LIMITED (JP) | 1995-03-14 | — | — | US | disclosed |
| EP-0551527-A1 | PYRROLOAZEPINE DERIVATIVE | SUNTORY LIMITED (JP) | 1993-07-21 | — | — | EP | disclosed |