Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.38 |
| ▸ | TP53 | P04637 | 3/20 | 0.37 |
| ▸ | GCGR | P47871 | 5/20 | 0.37 |
| ▸ | GIPR | P48546 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.35 |
| ▸ | PREP | P48147 | 1/20 | 0.35 |
| ▸ | LIPE | Q05469 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | ADCY6 | O43306 | 1/20 | 0.35 |
| ▸ | ADCY3 | O60266 | 1/20 | 0.35 |
| ▸ | ADCY9 | O60503 | 1/20 | 0.35 |
| ▸ | ADCY5 | O95622 | 1/20 | 0.35 |
| ▸ | ADCY8 | P40145 | 1/20 | 0.35 |
| ▸ | ADCY7 | P51828 | 1/20 | 0.35 |
| ▸ | ADCY2 | Q08462 | 1/20 | 0.35 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.35 |
| ▸ | ADCY4 | Q8NFM4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6992582 | 0.94 | TRPV1 (0.36) | TRPV1GCGRCTSSPREPSCN9A | |
| SCHEMBL6998484 | 0.93 | TRPV1 (0.39) | TRPV1GCGRPREPSCN9AADCY6 | |
| SCHEMBL7144829 | 0.92 | TRPV1 (0.42) | TRPV1GCGRPTGDR2PREPSCN9A | |
| SCHEMBL6988915 | 0.90 | IDO1 (0.42) | TP53LMNAPTGDR2 | |
| SCHEMBL6994067 | 0.88 | RAB9A (0.41) | TP53LMNAPTGDR2 | |
| SCHEMBL6989614 | 0.87 | TP53 (0.47) | TP53GCGRLMNAADCY6ADCY3 | |
| SCHEMBL6988021 | 0.85 | NPC1 (0.39) | TP53LMNA | |
| SCHEMBL6988551 | 0.84 | TP53 (0.35) | TP53GCGRGIPR | |
| SCHEMBL6997966 | 0.83 | MEN1 (0.34) | GCGRGIPR | |
| SCHEMBL6699086 | 0.83 | KLKB1 (0.43) | GCGRGIPRCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358176-A2 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | Amura Therapeutics Limited (GB) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002057246-A2 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | AMURA THERAPEUTICS LIMITED (GB) | 2002-07-25 | — | — | WO | disclosed |