Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 10/20 | 0.42 |
| ▸ | GCGR | P47871 | 2/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.34 |
| ▸ | PREP | P48147 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | CCR5 | P51681 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.33 |
| ▸ | TAOK3 | Q9H2K8 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | CCR3 | P51677 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6991739 | 0.92 | TRPV1 (0.38) | TRPV1GCGRPREPSCN9APTGDR2 | |
| SCHEMBL6992598 | 0.91 | AKT1 (0.38) | GCGRCCR5 | |
| SCHEMBL6992582 | 0.90 | TRPV1 (0.36) | TRPV1GCGREPHX2NR1H4PREP | |
| SCHEMBL6998484 | 0.89 | TRPV1 (0.39) | TRPV1GCGREPHX2PREPSCN9A | |
| SCHEMBL6992764 | 0.88 | HPGD (0.39) | GCGRPTGDR2TAOK1TAOK3CCR3 | |
| SCHEMBL6996937 | 0.88 | TP53 (0.40) | GCGREPHX2NR1H4 | |
| SCHEMBL6986470 | 0.85 | HPGD (0.38) | GCGR | |
| SCHEMBL6701575 | 0.82 | TRPV1 (0.44) | TRPV1 | |
| SCHEMBL6990244 | 0.82 | TP53 (0.38) | GCGRPTGDR2 | |
| SCHEMBL6988915 | 0.82 | IDO1 (0.42) | PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358176-A2 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | Amura Therapeutics Limited (GB) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002057246-A2 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | AMURA THERAPEUTICS LIMITED (GB) | 2002-07-25 | — | — | WO | disclosed |