Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 4/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 5/20 | 0.39 |
| ▸ | CA1 | P00915 | 6/20 | 0.35 |
| ▸ | CA2 | P00918 | 6/20 | 0.35 |
| ▸ | CA12 | O43570 | 4/20 | 0.35 |
| ▸ | CA9 | Q16790 | 4/20 | 0.35 |
| ▸ | CA4 | P22748 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7000063 | 0.89 | PTGS2 (0.45) | PTGS2CA1CA2CA12CA9 | |
| SCHEMBL6997787 | 0.87 | PTGS2 (0.40) | PTGS2CHRNA7CA1CA2CA12 | |
| SCHEMBL6996692 | 0.85 | RXRA (0.42) | PTGS2CHRNA7CA1CA2CA12 | |
| SCHEMBL6994970 | 0.85 | CA2 (0.46) | PTGS2CA1CA2CA12CA9 | |
| SCHEMBL7000178 | 0.85 | CA2 (0.46) | PTGS2CA1CA2CA12CA9 | |
| SCHEMBL7000891 | 0.84 | PGR (0.43) | PTGS2 | |
| SCHEMBL6999485 | 0.82 | CHRNA7 (0.44) | PTGS2CHRNA7CA1CA2CA9 | |
| SCHEMBL6994360 | 0.82 | CHRNA7 (0.44) | PTGS2CHRNA7CA1CA2CA9 | |
| SCHEMBL6998878 | 0.81 | PTGS2 (0.57) | PTGS2CA1CA2CA12CA9 | |
| SCHEMBL3232569 | 0.81 | CA2 (0.51) | PTGS2CHRNA7CA1CA2CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1109799-B1 | 4,5-DIARYL-3(2H)-FURANONE DERIVATIVES AS CYCLOOXYGENASE-2 INHIBITORS | PACIFIC CORP (KR) | 2003-12-17 | — | — | EP | claimed |
| US-6492416-B1 | TREATING INFLAMMATION AND ASSOCIATED DISORDERS | PACIFIC CORPORATION (KR) | 2002-12-10 | — | — | US | claimed |
| EP-1109799-B1 | 4,5-DIARYL-3(2H)-FURANONE DERIVATIVES AS CYCLOOXYGENASE-2 INHIBITORS | PACIFIC CORP (KR) | 2003-12-17 | — | — | EP | disclosed |
| US-6492416-B1 | TREATING INFLAMMATION AND ASSOCIATED DISORDERS | PACIFIC CORPORATION (KR) | 2002-12-10 | — | — | US | disclosed |