Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.51 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | CFTR | P13569 | 1/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | KDM6B | O15054 | 1/20 | 0.39 |
| ▸ | TET3 | O43151 | 1/20 | 0.39 |
| ▸ | KDM4A | O75164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6235518 | 0.86 | ALDH1A1 (0.49) | MAPTALDH1A1L3MBTL1SLC2A1PSEN1 | |
| SCHEMBL6991932 | 0.86 | MAPT (0.41) | MAPTALDH1A1L3MBTL1SLC2A1KMT2A | |
| SCHEMBL6992829 | 0.86 | MAPT (0.46) | MAPTALDH1A1L3MBTL1SLC2A1POLB | |
| SCHEMBL6238400 | 0.85 | SLC2A1 (0.46) | MAPTALDH1A1L3MBTL1SLC2A1POLB | |
| SCHEMBL5210605 | 0.85 | CFTR (0.55) | MAPTALDH1A1L3MBTL1KMT2ACFTR | |
| SCHEMBL6236957 | 0.85 | MAPT (0.51) | MAPTALDH1A1L3MBTL1SLC2A1KMT2A | |
| SCHEMBL6990533 | 0.82 | SLC2A1 (0.53) | MAPTALDH1A1SLC2A1KMT2A | |
| SCHEMBL6235516 | 0.79 | KDM4C (0.49) | MAPTALDH1A1L3MBTL1POLBKMT2A | |
| SCHEMBL5210601 | 0.78 | KDM4E (0.56) | MAPTALDH1A1L3MBTL1KMT2ACFTR | |
| SCHEMBL6989518 | 0.78 | ALDH1A1 (0.46) | MAPTALDH1A1L3MBTL1TP53THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1362033-A1 | PYRIDINE MATRIX METALLOPROTEINASE INHIBITORS | Warner-Lambert Company LLC (US) | 2003-11-19 | — | — | EP | claimed |
| WO-2002064568-A1 | PYRIDINE MATRIX METALLOPROTEINASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2002-08-22 | — | — | WO | claimed |