SCHEMBL6236957

SCHEMBL6236957

O=C(c1ccnc(C(=O)N(Cc2cccc(Cl)c2)Cc2cccc(Cl)c2)c1)N(Cc1cccc(Cl)c1)Cc1cccc(Cl)c1

nearest known ligand 0.51

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.51
L3MBTL1 Q9Y468 2/20 0.51
ALDH1A1 P00352 2/20 0.51
SMN1; SMN2 Q16637 1/20 0.51
SLC6A9 P48067 5/20 0.46
CNR2 P34972 1/20 0.44
SLC2A1 P11166 2/20 0.43
KMT2A Q03164 1/20 0.42
KCNH2 Q12809 2/20 0.41
SLC6A5 Q9Y345 2/20 0.41
HPGD P15428 1/20 0.41
PIN1 Q13526 1/20 0.41
KDM4C Q9H3R0 1/20 0.41
RIPK1 Q13546 1/20 0.40
CFTR P13569 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6991899 0.85 MAPT (0.51) MAPTL3MBTL1ALDH1A1SLC2A1KMT2A
SCHEMBL5210605 0.85 CFTR (0.55) MAPTL3MBTL1ALDH1A1KMT2AKDM4C
SCHEMBL6985142 0.84 PKM (0.46) MAPTL3MBTL1ALDH1A1SLC2A1KMT2A
SCHEMBL6990355 0.81 SLC2A1 (0.61) SMN1; SMN2SLC2A1HPGD
SCHEMBL6987913 0.80 KDM4E (0.48) L3MBTL1ALDH1A1SMN1; SMN2KMT2AHPGD
SCHEMBL6238400 0.79 SLC2A1 (0.46) MAPTL3MBTL1ALDH1A1SLC2A1KMT2A
SCHEMBL5210601 0.78 KDM4E (0.56) MAPTL3MBTL1ALDH1A1KMT2AKDM4C
SCHEMBL5214358 0.77 PPARG (0.55) MAPTL3MBTL1ALDH1A1KMT2ACFTR
SCHEMBL6989518 0.77 ALDH1A1 (0.46) MAPTL3MBTL1ALDH1A1SMN1; SMN2KMT2A
SCHEMBL6991932 0.77 MAPT (0.41) MAPTL3MBTL1ALDH1A1SLC2A1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1530467-A2 COMBINATION OF AN ALLOSTERIC CARBOXYLIC INHIBITOR OF MATRIX METALLOPROTEINASE-13 WITH CELECOXIB OR VALDECOXIB Warner-Lambert Company LLC (US) 2005-05-18 EP disclosed
WO-2004006912-A2 COMBINATION OF AN ALLOSTERIC CARBOXYLIC INHIBITOR OF MATRIX METALLOPROTEINASE-13 WITH CELECOXIB OR VALDECOXIB WARNER-LAMBERT COMPANY LLC (US) 2004-01-22 WO disclosed