Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | GPR55 | Q9Y2T6 | 2/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6994314 | 0.96 | ELANE (0.52) | ELANEKDM4EPKMLMNASMN1; SMN2 | |
| SCHEMBL6983796 | 0.94 | ELANE (0.39) | ELANEKDM4EPKMALDH1A1CYP2C19 | |
| SCHEMBL6993818 | 0.84 | ELANE (0.43) | ELANEKDM4EPKMLMNASMN1; SMN2 | |
| SCHEMBL7090352 | 0.80 | ELANE (0.48) | ELANEKDM4EPKMLMNASMN1; SMN2 | |
| SCHEMBL6992847 | 0.78 | ELANE (0.43) | ELANEKDM4EPKMNPSR1GPR55 | |
| SCHEMBL6987830 | 0.77 | ELANE (0.38) | ELANENPSR1GPR55MEN1KMT2A | |
| SCHEMBL6986467 | 0.74 | ELANE (0.39) | ELANEKDM4EPKMCYP2C19 | |
| SCHEMBL7512573 | 0.74 | ELANE (0.44) | ELANEKDM4EPKMLMNASMN1; SMN2 | |
| SCHEMBL14677996 | 0.74 | NR1H4 (0.48) | ELANEMEN1KMT2A | |
| SCHEMBL3833715 | 0.74 | NR1H4 (0.45) | ELANEKDM4EALDH1A1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1345918-A1 | CHEMICAL COMPOUNDS | AstraZeneca AB (SE) | 2003-09-24 | — | — | EP | disclosed |
| WO-2002050051-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2002-06-27 | — | — | WO | disclosed |