Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | PKM | P14618 | 2/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.34 |
| ▸ | LMNA | P02545 | 5/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.34 |
| ▸ | GPR55 | Q9Y2T6 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | PRNP | P04156 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6992847 | 0.88 | ELANE (0.43) | ELANECYP2C19KDM4EPKMNR1H4 | |
| SCHEMBL7512573 | 0.88 | ELANE (0.44) | ELANECYP2C19KDM4EPKMALDH1A1 | |
| SCHEMBL3833715 | 0.86 | NR1H4 (0.45) | ELANECYP2C19KDM4ENR1H4ALDH1A1 | |
| SCHEMBL6987940 | 0.85 | ELANE (0.48) | ELANECYP2C19KDM4EPKMALDH1A1 | |
| SCHEMBL6993226 | 0.85 | ELANE (0.41) | ELANECYP2C19KDM4EPKMALDH1A1 | |
| SCHEMBL6991971 | 0.84 | ELANE (0.48) | ELANECYP2C19KDM4EPKMALDH1A1 | |
| SCHEMBL6256758 | 0.84 | NR1H4 (0.50) | ELANENR1H4KMT2A | |
| SCHEMBL3835251 | 0.84 | NR1H4 (0.44) | ELANEKDM4ENR1H4ALDH1A1 | |
| SCHEMBL3836167 | 0.84 | NR1H4 (0.45) | ELANECYP2C19KDM4ENR1H4ALDH1A1 | |
| SCHEMBL6986488 | 0.83 | GAA (0.36) | ELANEKDM4EPKMALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1345918-A1 | CHEMICAL COMPOUNDS | AstraZeneca AB (SE) | 2003-09-24 | — | — | EP | disclosed |
| WO-2002050051-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2002-06-27 | — | — | WO | disclosed |