Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 4/20 | 0.38 |
| ▸ | PGR | P06401 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.34 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.31 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.30 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6986488 | 0.86 | GAA (0.36) | ELANEPGRALDH1A1NPSR1MEN1 | |
| SCHEMBL7086934 | 0.81 | ELANE (0.38) | ELANEPGRALDH1A1NPSR1GPR55 | |
| SCHEMBL6993818 | 0.79 | ELANE (0.43) | ELANEALDH1A1NPSR1GPR55MEN1 | |
| SCHEMBL6991971 | 0.77 | ELANE (0.48) | ELANEALDH1A1NPSR1GPR55MEN1 | |
| SCHEMBL6992526 | 0.74 | NR1H4 (0.40) | ALDH1A1 | |
| SCHEMBL6992847 | 0.74 | ELANE (0.43) | ELANEALDH1A1NPSR1GPR55 | |
| SCHEMBL6994314 | 0.74 | ELANE (0.52) | ELANEALDH1A1NPSR1GPR55MEN1 | |
| SCHEMBL7512573 | 0.73 | ELANE (0.44) | ELANEALDH1A1NPSR1GPR55MEN1 | |
| SCHEMBL6992850 | 0.71 | ELANE (0.40) | ELANEPGRALDH1A1NPSR1GPR55 | |
| SCHEMBL5225113 | 0.71 | SLC6A2 (0.37) | ELANEPGRALDH1A1NPSR1AMY1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1345918-A1 | CHEMICAL COMPOUNDS | AstraZeneca AB (SE) | 2003-09-24 | — | — | EP | disclosed |
| WO-2002050051-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2002-06-27 | — | — | WO | disclosed |