Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.51 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.48 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | STS | P08842 | 7/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | TYK2 | P29597 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2423448 | 0.83 | FAAH (0.52) | GPR119KDM4EMAPTTHRBJAK2 | |
| SCHEMBL6203854 | 0.82 | POLB (0.53) | GPR119KMT2A | |
| SCHEMBL948255 | 0.80 | GPR119 (0.53) | GPR119KDM4EMAPTTHRBJAK2 | |
| SCHEMBL6988822 | 0.78 | HTR1F (0.41) | KMT2AJAK2JAK1JAK3 | |
| SCHEMBL2539358 | 0.77 | HTR2B (0.55) | GPR119KDM4EMAPTTHRBJAK2 | |
| SCHEMBL22468956 | 0.77 | ALDH1A1 (0.54) | GPR119PTPN2PTPN1PTPN6HPGD | |
| SCHEMBL2425503 | 0.76 | KMT2A (0.45) | KDM4EKMT2AJAK3 | |
| SCHEMBL7465456 | 0.75 | PDE10A (0.56) | GPR119PTPN2PTPN1PTPN6STS | |
| SCHEMBL18228469 | 0.75 | GPR119 (0.58) | GPR119PTPN2PTPN1PTPN6HPGD | |
| SCHEMBL407896 | 0.75 | GPR119 (0.52) | GPR119PTPN2PTPN1PTPN6HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0588859-B1 | Imidazo[1,2-a](pyrrolo, thieno or furano)[3,2-d]azepine derivatives, compositions and methods of use | JANSSEN PHARMACEUTICA NV (BE) | 2003-08-13 | — | — | EP | disclosed |
| US-5461050-A | Antiallergens | JANSSEN PHARMACEUTICA N.V. (BE) | 1995-10-24 | — | — | US | disclosed |
| EP-0518434-A1 | Imidazo(1,2-a)(pyrrolo, thieno or furano)(3,2-d)azepine derivatives, compositions and methods of use | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-12-16 | — | — | EP | disclosed |