Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 3/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
| ▸ | RAD52 | P43351 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL9765246 | 0.81 | ADRA2A (0.43) | ADRA2AADRA2BADRA2CADRB2ADRA1A | |
| SCHEMBL7000150 | 0.79 | IDO1 (0.47) | ADRA2AADRA2BADRA2CADRB2ADRA1A | |
| SCHEMBL6994823 | 0.76 | KIF11 (0.40) | ADRA2AADRA2BADRA2CADRB2ADRA1A | |
| SCHEMBL25459623 | 0.74 | ESR1 (0.42) | ADRA2AADRA2BADRA2CESR1ESR2 | |
| SCHEMBL29890111 | 0.74 | ESR1 (0.42) | ADRA2AADRA2BADRA2CESR1ESR2 | |
| SCHEMBL2427206 | 0.73 | PDE2A (0.56) | ADRA2AADRA2BADRA2CADRA1ATAAR1 | |
| SCHEMBL2427205 | 0.73 | PDE2A (0.56) | ADRA2AADRA2BADRA2CADRA1ATAAR1 | |
| SCHEMBL8073211 | 0.73 | MEN1 (0.59) | CYP3A4HSD17B10KDM4ETDP1ESR1 | |
| SCHEMBL12263468 | 0.72 | LMNA (0.43) | ADRA2AADRA2BADRA2CADRA1ACYP3A4 | |
| SCHEMBL21950202 | 0.72 | PDE2A (0.42) | ADRA2AADRA2BADRA2CADRA1ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1069132-B1 | Bicyclic derivatives of amino-pyrazinones, process of preparation and pharmaceutical compositions comprising them | SERVIER LAB (FR) | 2003-10-01 | — | — | EP | disclosed |
| EP-1069132-A1 | Bicyclic derivatives of amino-pyrazinones, process of preparation and pharmaceutical compositions comprising them | ADIR ET COMPAGNIE (FR) | 2001-01-17 | — | — | EP | disclosed |