Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A known ✓ | P08913 | 3/20 | 0.43 |
| ▸ | ADRA2B known ✓ | P18089 | 3/20 | 0.43 |
| ▸ | ADRA2C known ✓ | P18825 | 3/20 | 0.43 |
| ▸ | ADRB2 known ✓ | P07550 | 2/20 | 0.43 |
| ▸ | ADRA1A known ✓ | P35348 | 2/20 | 0.43 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.37 |
| ▸ | ADRA1B known ✓ | P35368 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | RAD52 | P43351 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | NEK1 | Q96PY6 | 4/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24989713 | 0.83 | TSHR (0.47) | ADRA2AADRA2BADRA2CADRA1ACYP3A4 | |
| SCHEMBL6993618 | 0.81 | ADRA2A (0.46) | ADRA2AADRA2BADRA2CADRB2ADRA1A | |
| SCHEMBL3238423 | 0.80 | ESR1 (0.56) | ADRA2AADRA2BADRA2CADRB2ADRA1A | |
| SCHEMBL2427206 | 0.79 | PDE2A (0.56) | ADRA2AADRA2BADRA2CADRA1ANEK1 | |
| SCHEMBL2427205 | 0.79 | PDE2A (0.56) | ADRA2AADRA2BADRA2CADRA1ANEK1 | |
| SCHEMBL12263468 | 0.78 | LMNA (0.43) | ADRA2AADRA2BADRA2CADRA1ACYP3A4 | |
| SCHEMBL18839718 | 0.78 | APLNR (0.48) | ADRA2AADRA2BADRA2CADRB2ADRA1A | |
| SCHEMBL29784759 | 0.78 | APLNR (0.48) | ADRA2AADRA2BADRA2CADRB2ADRA1A | |
| SCHEMBL22823679 | 0.77 | FFAR1 (0.42) | ADRA2AADRA2BADRA2CCYP3A4 | |
| Ammonia Solution, Strong SCHEMBL7990638 | 0.76 | TYR (0.44) | ADRA2AADRA2BADRA2CESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0255728-B1 | PHENOXYACETIC ACID COMPOUNDS, THEIR PREPARATION, PHARMACEUTICAL COMPOSITION AND USE | TANABE SEIYAKU CO., LTD. (JP) | 1991-11-27 | — | — | EP | disclosed |
| US-4866196-A | ANTICOAGULANTS | TANABE SEIYAKU CO., LTD. (JP) | 1989-09-12 | — | — | US | disclosed |
| EP-0255728-A2 | Phenoxyacetic acid compounds, their preparation, pharmaceutical composition and use | TANABE SEIYAKU CO., LTD. (JP) | 1988-02-10 | — | — | EP | disclosed |