Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 3/20 | 0.56 |
| ▸ | ESR1 | P03372 | 6/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.40 |
| ▸ | MIF | P14174 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TYR | P14679 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.38 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2427206 | 1.00 | PDE2A (0.56) | PDE2AESR1ADRB1MIFHTR2A | |
| SCHEMBL12263468 | 0.83 | LMNA (0.43) | PDE2AESR1ADRA1AHTR2BADRA2A | |
| Ammonia Solution, Strong SCHEMBL7990638 | 0.81 | TYR (0.44) | PDE2AESR1ADRA2AADRA2BADRA2C | |
| SCHEMBL27798663 | 0.79 | ADRA2A (0.40) | PDE2AESR1MIFADRA2AADRA2B | |
| Bromide SCHEMBL9765246 | 0.79 | ADRA2A (0.43) | ESR1ADRA1AADRA2AADRA2BADRA2C | |
| SCHEMBL29673215 | 0.78 | PDE2A (0.60) | PDE2AHTR2ALMNATP53HTT | |
| SCHEMBL29668983 | 0.78 | PDE2A (0.60) | PDE2AHTR2ALMNATP53HTT | |
| SCHEMBL22503911 | 0.78 | TYR (0.55) | ESR1ADRB1MIFHTR2AADRA1A | |
| SCHEMBL29673197 | 0.78 | PDE2A (0.60) | PDE2AHTR2ALMNATP53HTT | |
| SCHEMBL1761854 | 0.78 | PDE2A (0.60) | PDE2AHTR2ALMNATP53HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101910168-B | Tropane compounds | EXELIXIS INC | 2014-07-30 | — | — | CN | disclosed |
| US-8012956-B2 | Tropane compounds | EXELIXIS, INC. (US) | 2011-09-06 | — | — | US | disclosed |
| CN-101910168-A | Tropane compounds | EXELIXIS INC | 2010-12-08 | — | — | CN | disclosed |
| EP-2074120-B1 | TROPANE COMPOUNDS | EXELIXIS INC (US) | 2010-03-03 | — | — | EP | disclosed |
| US-20090163471-A1 | Tropane compounds | EXELIXIS, INC. | 2009-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090163471-A1 | Tropane compounds | ADRA1B, ADRA2B, ADRB2 | PDE2A 255/4885ESR1 360/4885ADRB1 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.