Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA2 | P42262 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | TDP2 | O95551 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | XBP1 | P17861 | 1/20 | 0.39 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.39 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | GABRP | O00591 | 1/20 | 0.38 |
| ▸ | GABRD | O14764 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6997430 | 0.89 | GRIA2 (0.46) | GRIA2CYP1A2CYP3A4CYP2C9MAPK1 | |
| SCHEMBL7607849 | 0.89 | CYP1A2 (0.61) | GRIA2CYP1A2CYP3A4CYP2C9MAPK1 | |
| SCHEMBL6996884 | 0.87 | MAPT (0.42) | GRIA2CYP1A2CYP3A4CYP2C9MAPK1 | |
| SCHEMBL6994166 | 0.85 | MAPT (0.50) | GRIA2CYP1A2CYP3A4CYP2C9MAPK1 | |
| SCHEMBL7453036 | 0.84 | ROCK2 (0.54) | GRIA2CYP1A2CYP3A4CYP2C9MAPK1 | |
| SCHEMBL6625258 | 0.82 | GRIA2 (0.61) | GRIA2CYP1A2CYP3A4CYP2C9MAPK1 | |
| SCHEMBL7226645 | 0.81 | CYP1A2 (0.55) | GRIA2CYP1A2CYP3A4CYP2C9MAPK1 | |
| SCHEMBL7228098 | 0.81 | CYP1A2 (0.62) | GRIA2CYP1A2CYP3A4CYP2C9MAPK1 | |
| SCHEMBL6935103 | 0.77 | MAPT (0.44) | GRIA2CYP1A2CYP3A4CYP2C9MAPK1 | |
| SCHEMBL6936559 | 0.76 | MAPT (0.47) | CYP1A2CYP3A4CYP2C9MAPK1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001956-B1 | 2,3-BENZODIAZEPINE DERIVATIVES | GYOGYSZERKUTATO INTEZET (HU) | 2003-05-07 | — | — | EP | disclosed |
| US-6482819-B1 | 2,3-benzodiazepine derivatives | GYOGYSZERKUTATO INTEZET KFT. (HU) | 2002-11-19 | — | — | US | disclosed |
| EP-1001956-A1 | NEW 2,3-BENZODIAZEPINE DERIVATIVES | GYOGYSZERKUTATO INTEZET KFT. (HU) | 2000-05-24 | — | — | EP | disclosed |
| WO-1999006408-A1 | NEW 2,3-BENZODIAZEPINE DERIVATIVES | Gyógyszerkutató Intézet Kft. (HU) | 1999-02-11 | — | — | WO | disclosed |