Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | PPOX | P50336 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.33 |
| ▸ | ELANE | P08246 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.31 |
| ▸ | PGR | P06401 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6992847 | 0.89 | ELANE (0.43) | GAAPKMALDH1A1PPOXKDM4E | |
| SCHEMBL6987830 | 0.86 | ELANE (0.38) | ALDH1A1L3MBTL1ELANEMEN1KMT2A | |
| SCHEMBL6993818 | 0.83 | ELANE (0.43) | GAAPKMALDH1A1L3MBTL1KDM4E | |
| SCHEMBL6993131 | 0.80 | ELANE (0.41) | GAAPKMALDH1A1PPOXKDM4E | |
| SCHEMBL6992526 | 0.78 | NR1H4 (0.40) | ALDH1A1KDM4E | |
| SCHEMBL7507444 | 0.78 | ELANE (0.45) | GAAPKMALDH1A1PPOXKDM4E | |
| SCHEMBL6993226 | 0.78 | ELANE (0.41) | PKMALDH1A1KDM4EELANEMEN1 | |
| Ethyl Bromo Acetate SCHEMBL7509727 | 0.77 | ALDH1A1 (0.39) | GAAPKMALDH1A1PPOXKDM4E | |
| SCHEMBL6993400 | 0.76 | ELANE (0.42) | GAAPKMALDH1A1L3MBTL1PPOX | |
| SCHEMBL14677996 | 0.73 | NR1H4 (0.48) | TDP1ELANEMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1345918-A1 | CHEMICAL COMPOUNDS | AstraZeneca AB (SE) | 2003-09-24 | — | — | EP | disclosed |
| WO-2002050051-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2002-06-27 | — | — | WO | disclosed |