Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PDE2A | O00408 | 3/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7383720 | 0.93 | FAAH (0.33) | FAAHSMN1; SMN2GRIK1 | |
| SCHEMBL6997649 | 0.89 | LMNA (0.38) | LMNAPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6995428 | 0.88 | DRD2 (0.38) | LMNAPDE2APDE4APDE4BPDE4C | |
| SCHEMBL7895726 | 0.85 | PDE2A (0.41) | PDE2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7001343 | 0.80 | SMN1; SMN2 (0.35) | LMNASMN1; SMN2 | |
| SCHEMBL7510987 | 0.79 | LMNA (0.39) | LMNAPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6992446 | 0.78 | LMNA (0.38) | LMNAPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7885863 | 0.76 | MEN1 (0.42) | PDE2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7409812 | 0.74 | PDE2A (0.36) | PDE2AGRIK1 | |
| SCHEMBL7851968 | 0.74 | DAGLA (0.37) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0973774-B1 | 1,5-DIHYDRO-PYRAZOLO 3,4-D]-PYRIMIDINONE DERIVATIVES | BAYER AG (DE) | 2003-01-22 | — | — | EP | disclosed |
| EP-0973774-A1 | 1,5-DIHYDRO-PYRAZOLO 3,4-D]-PYRIMIDINONE DERIVATIVES | BAYER AG (DE) | 2000-01-26 | — | — | EP | disclosed |
| WO-1998040384-A1 | 1,5-DIHYDRO-PYRAZOLO[3,4-D]-PYRIMIDINONE DERIVATIVES | BAYER AKTIENGESELLSCHAFT (DE) | 1998-09-17 | — | — | WO | disclosed |