Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 8/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | MTOR | P42345 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | WNT3A | P56704 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.36 |
| ▸ | MAP3K6 | O95382 | 1/20 | 0.36 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | WNT1 | P04628 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30636341 | 0.80 | GSK3B (0.60) | NOTUMABL1CHEK1MTORGSK3B | |
| SCHEMBL28166698 | 0.80 | GSK3B (0.60) | NOTUMABL1CHEK1MTORGSK3B | |
| SCHEMBL7384572 | 0.80 | NOTUM (0.46) | NOTUMABL1CHEK1MTORWNT3A | |
| SCHEMBL9606797 | 0.72 | CTSK (0.41) | NOTUMABL1CHEK1MTORGSK3B | |
| SCHEMBL3633134 | 0.71 | PAX8 (0.43) | NOTUMKDM4EALDH1A1 | |
| SCHEMBL2319091 | 0.71 | NOTUM (0.56) | NOTUMABL1CHEK1MTORWNT3A | |
| SCHEMBL12376736 | 0.71 | CHEK1 (0.56) | NOTUMCHEK1MTORTRPV1WNT3A | |
| SCHEMBL7093982 | 0.71 | GSK3B (0.47) | NOTUMABL1CHEK1MTORGSK3B | |
| SCHEMBL7093981 | 0.71 | GSK3B (0.47) | NOTUMABL1CHEK1MTORGSK3B | |
| SCHEMBL254369 | 0.70 | SIGMAR1 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1023268-B1 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER LTD (GB) | 2003-05-21 | — | — | EP | disclosed |