Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | CTSK | P43235 | 1/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ABL1 | P00519 | 6/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | WNT3A | P56704 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6994498 | 0.80 | NOTUM (0.46) | NOTUMCTSKCHEK1ALDH1A1KDM4E | |
| SCHEMBL7385006 | 0.76 | SMN1; SMN2 (0.38) | CTSKALDH1A1KDM4ESMN1; SMN2TSHR | |
| SCHEMBL213675 | 0.71 | NOTUM (0.49) | NOTUMCTSKCHEK1ALDH1A1KDM4E | |
| SCHEMBL27449890 | 0.71 | TSHR (0.60) | ALDH1A1KDM4ESMN1; SMN2TSHRCYP1A2 | |
| SCHEMBL2574304 | 0.71 | EPHX1 (0.61) | NOTUMCTSKCHEK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL215046 | 0.70 | ALDH1A1 (0.48) | NOTUMCTSKCHEK1ALDH1A1KDM4E | |
| SCHEMBL2837600 | 0.70 | CTSK (0.52) | NOTUMCTSKCHEK1ALDH1A1KDM4E | |
| SCHEMBL213835 | 0.69 | KDM4E (0.47) | NOTUMCTSKCHEK1ALDH1A1KDM4E | |
| SCHEMBL2319091 | 0.68 | NOTUM (0.56) | NOTUMCHEK1ALDH1A1KDM4EABL1 | |
| SCHEMBL2837602 | 0.68 | NOTUM (0.46) | NOTUMCTSKCHEK1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1023268-A1 | ISOQUINOLINES AS UROKINASE INHIBITORS | Pfizer Limited (GB) | 2000-08-02 | — | — | EP | disclosed |
| WO-1999020608-A1 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER LIMITED (GB) | 1999-04-29 | — | — | WO | disclosed |