Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 2/20 | 0.41 |
| ▸ | HPGDS | O60760 | 1/20 | 0.40 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.39 |
| ▸ | TUBB | P07437 | 1/20 | 0.39 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.39 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.39 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.39 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.39 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.39 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8189660 | 0.88 | POLB (0.53) | TDP1POLBL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL6998322 | 0.81 | ALDH1A1 (0.46) | TDP1POLBALDH1A1KDM4EHPGD | |
| SCHEMBL27460074 | 0.80 | ALDH1A1 (0.38) | TDP1POLBL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL1549482 | 0.73 | DHODH (0.55) | TDP1ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL31540409 | 0.73 | DHODH (0.55) | TDP1ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL8127740 | 0.72 | POLB (1.00) | TDP1POLBL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL8187620 | 0.71 | KDM4E (0.51) | POLBL3MBTL1ALDH1A1KDM4EHPGD | |
| SCHEMBL7001436 | 0.70 | SCD5 (0.41) | HSD17B10 | |
| SCHEMBL1553666 | 0.70 | ALDH1A1 (0.44) | TDP1POLBALDH1A1KDM4EHPGD | |
| SCHEMBL27729535 | 0.70 | PRKCZ (0.54) | TDP1ALDH1A1KDM4EHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0982308-B1 | Derivatives of the 8H-(2,3-b)-pyrrolizine-8-one, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-02-26 | — | — | EP | disclosed |
| EP-0982308-A1 | Derivatives of the 8H-(2,3-b)-pyrrolizine-8-one, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 2000-03-01 | — | — | EP | disclosed |