Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 5/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 5/20 | 0.36 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 3/20 | 0.35 |
| ▸ | HTR7 | P34969 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.35 |
| ▸ | PPIB | P23284 | 1/20 | 0.35 |
| ▸ | PPID | Q08752 | 1/20 | 0.35 |
| ▸ | PPIG | Q13427 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6995942 | 0.70 | TDP1 (0.55) | HSD17B10 | |
| SCHEMBL8189660 | 0.69 | POLB (0.53) | HSD17B10 | |
| SCHEMBL5194432 | 0.69 | HSP90AA1 (0.58) | SCD5HSP90AA1HSP90AB1HSD17B10PPIB | |
| SCHEMBL27460074 | 0.69 | ALDH1A1 (0.38) | HSP90AA1HSP90AB1HSD17B10 | |
| SCHEMBL31648898 | 0.67 | HSP90AA1 (0.50) | SCD5HSP90AA1HSP90AB1PPIBPPID | |
| SCHEMBL4776278 | 0.62 | RIPK1 (0.65) | SCD5HSP90AA1HSP90AB1PPID | |
| Formamide SCHEMBL4480338 | 0.62 | HSD11B1 (0.37) | HSP90AA1HSP90AB1PPIBPPIDPPIG | |
| SCHEMBL4563122 | 0.61 | SCD5 (0.42) | SCD5TRPV1HCRTR1HCRTR2ROCK2 | |
| SCHEMBL3538079 | 0.61 | SCD5 (0.47) | SCD5HCRTR1HCRTR2UCHL1USP30 | |
| SCHEMBL6998322 | 0.60 | ALDH1A1 (0.46) | HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0982308-B1 | Derivatives of the 8H-(2,3-b)-pyrrolizine-8-one, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-02-26 | — | — | EP | disclosed |
| EP-0982308-A1 | Derivatives of the 8H-(2,3-b)-pyrrolizine-8-one, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 2000-03-01 | — | — | EP | disclosed |