Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | DHODH | Q02127 | 2/20 | 0.44 |
| ▸ | HPGDS | O60760 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.40 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8187620 | 0.87 | KDM4E (0.51) | ALDH1A1KDM4EHPGDHSD17B10POLB | |
| SCHEMBL6995942 | 0.81 | TDP1 (0.55) | ALDH1A1KDM4EHPGDHSD17B10TDP1 | |
| SCHEMBL27729535 | 0.79 | PRKCZ (0.54) | ALDH1A1KDM4EHPGDHSD17B10TDP1 | |
| SCHEMBL6271882 | 0.77 | ALDH1A1 (0.54) | ALDH1A1KDM4EHPGDHSD17B10TDP1 | |
| SCHEMBL27460897 | 0.77 | KDM4E (0.39) | ALDH1A1KDM4EHPGDHSD17B10TDP1 | |
| SCHEMBL1549482 | 0.77 | DHODH (0.55) | ALDH1A1KDM4EHPGDHSD17B10TDP1 | |
| SCHEMBL31540409 | 0.77 | DHODH (0.55) | ALDH1A1KDM4EHPGDHSD17B10TDP1 | |
| SCHEMBL17258267 | 0.74 | HTT (0.54) | ALDH1A1KDM4EHPGDHSD17B10TDP1 | |
| SCHEMBL4082672 | 0.72 | TUBB4A (0.55) | ALDH1A1KDM4EHPGDHSD17B10TDP1 | |
| SCHEMBL6909617 | 0.72 | CA2 (0.41) | ALDH1A1KDM4EHPGDHSD17B10TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0982308-B1 | Derivatives of the 8H-(2,3-b)-pyrrolizine-8-one, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-02-26 | — | — | EP | disclosed |
| EP-0982308-A1 | Derivatives of the 8H-(2,3-b)-pyrrolizine-8-one, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 2000-03-01 | — | — | EP | disclosed |