SCHEMBL6997045

SCHEMBL6997045

c1ccc(CNC2CC3CCC(C2)N3Cc2ccccc2)cc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACHE P22303 6/20 0.58
BACE1 P56817 6/20 0.58
BCHE P06276 4/20 0.58
ALDH1A1 P00352 3/20 0.57
MEN1 O00255 4/20 0.54
KMT2A Q03164 4/20 0.54
L3MBTL1 Q9Y468 1/20 0.53
CYP2D6 P10635 1/20 0.52
CYP2C19 P33261 1/20 0.52
MAPT P10636 1/20 0.52
MAPK1 P28482 1/20 0.52
CHRM2 P08172 1/20 0.51
CHRM4 P08173 1/20 0.51
CHRM5 P08912 1/20 0.51
LMNA P02545 1/20 0.51
LTA4H P09960 1/20 0.51
PLA2G1B P04054 1/20 0.51
ALPL P05186 1/20 0.51
NPSR1 Q6W5P4 1/20 0.51
ATG4B Q9Y4P1 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6997039 1.00 ACHE (0.58) ACHEBACE1BCHEALDH1A1MEN1
SCHEMBL14388279 0.86 ACHE (0.49) ACHEBACE1BCHEALDH1A1MEN1
SCHEMBL9866831 0.86 ALDH1A1 (0.56) ALDH1A1MEN1KMT2AL3MBTL1CYP2D6
SCHEMBL31210789 0.82 ALDH1A1 (0.58) ALDH1A1MEN1KMT2AL3MBTL1CYP2D6
SCHEMBL12530366 0.82 ALDH1A1 (0.62) ALDH1A1MEN1KMT2AL3MBTL1CYP2D6
SCHEMBL6536312 0.82 ALDH1A1 (0.58) ALDH1A1MEN1KMT2AL3MBTL1CYP2D6
SCHEMBL15071683 0.82 ALDH1A1 (0.58) ALDH1A1MEN1KMT2AL3MBTL1CYP2D6
SCHEMBL7460731 0.82 CARM1 (0.52) ACHEBACE1BCHEMEN1KMT2A
SCHEMBL15071539 0.82 ALDH1A1 (0.58) ALDH1A1MEN1KMT2AL3MBTL1CYP2D6
SCHEMBL3040863 0.79 LTA4H (0.77) LTA4H

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0888351-B1 PYRIMIDO 5,4-D]PYRIMIDINES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION THOMAE GMBH DR K (DE) 2003-10-15 EP disclosed
EP-0888351-A1 PYRIMIDO 5,4-D]PYRIMIDINES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION Dr. Karl Thomae GmbH (DE) 1999-01-07 EP disclosed
WO-1997032880-A1 PYRIMIDO[5,4-D]PYRIMIDINES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION DR. KARL THOMAE GMBH (DE) 1997-09-12 WO disclosed