Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 10/20 | 0.56 |
| ▸ | DRD3 | P35462 | 8/20 | 0.56 |
| ▸ | DRD4 | P21917 | 6/20 | 0.56 |
| ▸ | HTR1A | P08908 | 3/20 | 0.53 |
| ▸ | HTR2A | P28223 | 2/20 | 0.53 |
| ▸ | HTR7 | P34969 | 1/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.51 |
| ▸ | DRD1 | P21728 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7950558 | 0.99 | DRD2 (0.55) | DRD2DRD3DRD4HTR1AHTR2A | |
| SCHEMBL6999464 | 0.81 | HTR7 (0.41) | DRD2DRD3DRD4HTR1AHTR2A | |
| Hydrochloric Acid SCHEMBL6990810 | 0.80 | SLC2A1 (0.41) | DRD2DRD3DRD4HTR1AHTR2A | |
| SCHEMBL6999138 | 0.78 | HTR7 (0.42) | DRD2DRD3DRD4HTR1AHTR2A | |
| Hydrochloric Acid SCHEMBL7943817 | 0.77 | HTR7 (0.42) | DRD2DRD3DRD4HTR1AHTR2A | |
| SCHEMBL15748302 | 0.77 | HTR1A (0.58) | DRD2DRD3HTR1AHTR7SLC6A2 | |
| SCHEMBL6526368 | 0.77 | DRD2 (0.85) | DRD2DRD3HTR1AHTR2AHTR7 | |
| SCHEMBL6992487 | 0.75 | NOS3 (0.51) | HTR7 | |
| SCHEMBL15326104 | 0.75 | DRD2 (0.54) | DRD2DRD3DRD4HTR1AHTR2A | |
| SCHEMBL6995702 | 0.74 | HTR7 (0.44) | DRD2HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1023898-B1 | Cyano-indoles as serotonine reuptake inhibitors and as 5-HT2c receptor ligands | SERVIER LAB (FR) | 2003-03-12 | — | — | EP | disclosed |
| EP-1023898-A1 | Cyano-indoles as serotonine reuptake inhibitors and as 5-HT2c receptor ligands | ADIR ET COMPAGNIE (FR) | 2000-08-02 | — | — | EP | disclosed |