Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.49 |
| ▸ | HTR1A | P08908 | 17/20 | 0.45 |
| ▸ | ADRA1D | P25100 | 15/20 | 0.45 |
| ▸ | HTR1B | P28222 | 15/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 15/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 15/20 | 0.45 |
| ▸ | HTR7 | P34969 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
| ▸ | DRD3 | P35462 | 2/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7718477 | 0.84 | HTR1A (0.61) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| SCHEMBL6999722 | 0.82 | HTR1A (0.56) | SIGMAR1HTR1AADRA1DHTR1BADRA1A | |
| SCHEMBL6999823 | 0.82 | HTR1A (0.56) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| SCHEMBL6992679 | 0.81 | HTR1A (0.49) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| SCHEMBL3457893 | 0.78 | SIGMAR1 (0.49) | SIGMAR1HTR1AADRA1DHTR1BADRA1A | |
| SCHEMBL6999544 | 0.78 | NPC1 (0.60) | SIGMAR1HTR1AADRA1DHTR1BADRA1A | |
| SCHEMBL6994547 | 0.77 | HTR1A (0.57) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| SCHEMBL7002568 | 0.77 | HTR1A (0.50) | SIGMAR1HTR1AADRA1DHTR1BADRA1A | |
| SCHEMBL7001787 | 0.77 | HTR1A (0.75) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| SCHEMBL6997759 | 0.77 | HTR1A (0.75) | HTR1AADRA1DHTR1BADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1023296-B1 | 3-SUBSTITUTED PYRIDO 3',4':4,5] THIENO 2,3-D] PYRIMIDINE DERIVATIVES, AND PRODUCTION AND USE OF THE SAME | ABBOTT GMBH & CO KG (DE) | 2003-12-17 | — | — | EP | disclosed |
| US-6159981-A | 3-substituted pyrido [3',4':4,5] Thieno [2,3-d] pyrimidine derivatives, and production and use of the same | BASF AKTIENGESELLSCHAFT (DE) | 2000-12-12 | — | — | US | disclosed |