Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.48 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.48 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.45 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.40 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.37 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.37 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 2/20 | 0.34 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14481009 | 0.83 | GABRA1 (0.50) | BRPF1PABPC1APOBEC3AAPOBEC3GHDAC8 | |
| SCHEMBL4818630 | 0.81 | GABRA1 (0.45) | BRPF1PABPC1APOBEC3AAPOBEC3GHDAC8 | |
| SCHEMBL2759567 | 0.81 | CASP3 (0.53) | BRPF1PABPC1APOBEC3AAPOBEC3GHDAC8 | |
| SCHEMBL607738 | 0.81 | LMNA (0.51) | BRPF1GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL14552559 | 0.78 | CLK4 (0.46) | BRPF1PABPC1APOBEC3AAPOBEC3GHDAC8 | |
| SCHEMBL1364964 | 0.77 | BRPF1 (0.64) | BRPF1PABPC1APOBEC3AAPOBEC3GGABRA1 | |
| SCHEMBL7556897 | 0.77 | CASP3 (0.57) | NR1H2NR1H3BRPF1GABRA1GABRG2 | |
| Ammonia Solution, Strong SCHEMBL9389187 | 0.76 | BRPF1 (0.62) | BRPF1PABPC1APOBEC3AAPOBEC3GGABRA1 | |
| SCHEMBL2060799 | 0.75 | NR1H2 (0.41) | NR1H2NR1H3ATAD2MEN1KMT2A | |
| SCHEMBL29249885 | 0.75 | BRPF1 (0.45) | BRPF1PABPC1APOBEC3AAPOBEC3GHDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1117659-B1 | SUBSTITUTED 3-CYANOQUINOLINES AS PROTEIN TYROSINE KINASES INHIBITORS | WYETH CORP (US) | 2003-12-03 | — | — | EP | disclosed |
| US-6288082-B1 | COMPOUNDS SUCH AS 6,7-DIETHOXY-4-(INDAN-5-YLAMINO) -QUINOLINE-3-CARBONITRILE USED AS ANTINEOPLASTIC AGENTS AND IN THE TREATMENT OF POLYCYCSTIC KIDNEY DISEASE | AMERICAN CYANAMID COMPANY | 2001-09-11 | — | — | US | disclosed |
| EP-1117659-A1 | SUBSTITUTED 3-CYANOQUINOLINES AS PROTEIN TYROSINE KINASES INHIBITORS | American Cyanamid Company (US) | 2001-07-25 | — | — | EP | disclosed |
| WO-2000018761-A1 | SUBSTITUTED 3-CYANOQUINOLINES AS PROTEIN TYROSINE KINASES INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 2000-04-06 | — | — | WO | disclosed |