Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.45 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | DAO | P14920 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MAOB | P27338 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.41 |
| ▸ | CTSB | P07858 | 2/20 | 0.40 |
| ▸ | XDH | P47989 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22275697 | 0.85 | POLB (0.46) | POLBDNMT1CTDSP1TDP1LMNA | |
| SCHEMBL4082463 | 0.76 | CXCR2 (0.47) | POLBDNMT1CTDSP1TDP1ALDH1A1 | |
| SCHEMBL22275638 | 0.73 | CTSB (0.40) | POLBDNMT1CTDSP1TDP1LMNA | |
| SCHEMBL11700115 | 0.68 | DRD2 (0.50) | POLBLMNAMAOBKMT2AL3MBTL1 | |
| SCHEMBL5637832 | 0.68 | AHR (0.47) | POLBDAOLMNAMAOBALDH1A1 | |
| SCHEMBL3691200 | 0.67 | POLB (0.35) | POLBDNMT1CTDSP1TDP1MAPT | |
| SCHEMBL7918830 | 0.67 | ALDH1A1 (0.47) | POLBTDP1LMNAALDH1A1MAPT | |
| SCHEMBL11702770 | 0.67 | MAOA (0.54) | DAOMAOBMAOADDB1CRBN | |
| SCHEMBL28800703 | 0.67 | S100A4 (0.63) | POLBDAOLMNAMAOBALDH1A1 | |
| SCHEMBL3163430 | 0.65 | MAPT (0.65) | LMNAMAOBALDH1A1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1257555-B1 | PYRIMIDINE COMPOUNDS AND THEIR USE AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | ASTRAZENECA AB (SE) | 2003-12-03 | — | — | EP | disclosed |
| EP-1257555-A1 | PYRIMIDINE COMPOUNDS AND THEIR USE AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | AstraZeneca AB (SE) | 2002-11-20 | — | — | EP | disclosed |
| WO-2001058906-A1 | PYRIMIDINE COMPOUNDS AND THEIR USE AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | ASTRAZENECA AB (SE) | 2001-08-16 | — | — | WO | disclosed |