Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 2/20 | 0.38 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.37 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6997418 | 0.81 | CDK4 (0.39) | CYP4F2CYP4A11HDAC6CDK4CCND1 | |
| SCHEMBL716520 | 0.77 | LMNA (0.53) | SMN1; SMN2LTA4HCYP4F2CYP4A11LMNA | |
| Hydrochloric Acid SCHEMBL28746969 | 0.76 | LMNA (0.51) | SMN1; SMN2LTA4HCYP4F2CYP4A11LMNA | |
| SCHEMBL6990085 | 0.75 | SMN1; SMN2 (0.43) | SMN1; SMN2ALOX5LTA4HCYP4F2CYP4A11 | |
| SCHEMBL5162771 | 0.73 | ALDH1A1 (0.49) | SMN1; SMN2LMNAL3MBTL1MAPTTDP1 | |
| SCHEMBL3095592 | 0.73 | LMNA (0.49) | SMN1; SMN2LMNAL3MBTL1MAPTTDP1 | |
| SCHEMBL7195997 | 0.73 | L3MBTL1 (0.43) | SMN1; SMN2ALOX5LTA4HCYP4F2CYP4A11 | |
| SCHEMBL671053 | 0.72 | CA12 (0.53) | SMN1; SMN2LMNAMAPTCYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL27813064 | 0.71 | CA12 (0.52) | SMN1; SMN2LMNAMAPTCYP1A2CYP3A4 | |
| SCHEMBL826081 | 0.69 | ALDH1A1 (0.45) | SMN1; SMN2MAPTALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0915881-B1 | PYRROLOAZEPINE COMPOUNDS | SUNTORY LTD (JP) | 2003-01-08 | — | — | EP | disclosed |
| US-6211362-B1 | CHEMICAL INTERMEDIATE FOR DRUGS | SUNTORY LIMITED (JP) | 2001-04-03 | — | — | US | disclosed |
| US-6187772-B1 | Pyrroloazepine compounds | SUNTORY LIMITED (JP) | 2001-02-13 | — | — | US | disclosed |
| EP-0915881-A1 | PYRROLOAZEPINE COMPOUNDS | SUNTORY LIMITED (JP) | 1999-05-19 | — | — | EP | disclosed |
| WO-1998041527-A1 | PYRROLOAZEPINE COMPOUNDS | SUNTORY LIMITED (JP) | 1998-09-24 | — | — | WO | disclosed |