SCHEMBL7002407

SCHEMBL7002407

COC(=O)N(C(=O)[C@@H](N)C(C)C)C(=O)[C@@H]1CCCN1[C@H](C(=O)c1nnc(C(C)(C)c2ccc3c(c2)OCO3)o1)C(C)C

nearest known ligand 0.41

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
ELANE P08246 1/20 0.41
FKBP1A P62942 1/20 0.32
TRPV1 Q8NER1 1/20 0.30
NPSR1 Q6W5P4 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7007709 0.89 ELANE (0.38) ELANE
SCHEMBL7005076 0.85 DPP4 (0.38) ELANE
SCHEMBL7205640 0.80 MCHR1 (0.36)
Hydrochloric Acid SCHEMBL7125040 0.76 ELANE (0.51) ELANE
SCHEMBL7200171 0.75 CNR2 (0.32)
SCHEMBL7201093 0.73 DPP4 (0.30)
SCHEMBL7201776 0.73
SCHEMBL7201125 0.72
SCHEMBL7202223 0.72
SCHEMBL7203915 0.72 ADRA1D (0.33) NPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20030216324-A1 Airway mucus secretion inhibitors ONO PHARMACEUTICAL CO., LTD. (JP) 2003-11-20 US claimed
US-20030212115-A1 Remedies for inflammatory bowel diseases ONO PHARMACEUTICAL CO., LTD. (JP) 2003-11-13 US claimed
EP-1323419-A1 AIRWAY MUCUS SECRETION INHIBITORS ONO PHARMACEUTICAL CO., LTD. (JP) 2003-07-02 EP claimed
EP-1323420-A1 REMEDIES FOR INFLAMMATORY BOWEL DISEASES ONO PHARMACEUTICAL CO., LTD. (JP) 2003-07-02 EP claimed
US-20030216324-A1 Airway mucus secretion inhibitors ONO PHARMACEUTICAL CO., LTD. (JP) 2003-11-20 US disclosed
US-20030212115-A1 Remedies for inflammatory bowel diseases ONO PHARMACEUTICAL CO., LTD. (JP) 2003-11-13 US disclosed
EP-1323420-A1 REMEDIES FOR INFLAMMATORY BOWEL DISEASES ONO PHARMACEUTICAL CO., LTD. (JP) 2003-07-02 EP disclosed
EP-1323419-A1 AIRWAY MUCUS SECRETION INHIBITORS ONO PHARMACEUTICAL CO., LTD. (JP) 2003-07-02 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030212115-A1 Remedies for inflammatory bowel diseases NOS3, TPMT, NOS2 ELANE 588/4885FKBP1A 2226/4885TRPV1 1338/4885
US-20030216324-A1 Airway mucus secretion inhibitors MUC1, CFTR, SERPINB1 ELANE 19/4885FKBP1A 4009/4885TRPV1 337/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.