Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FBP1 | P09467 | 8/20 | 0.45 |
| ▸ | PTGES | O14684 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.38 |
| ▸ | TUBB | P07437 | 1/20 | 0.38 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.38 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.38 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.38 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.38 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.38 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.38 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.38 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.38 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.38 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7004612 | 0.86 | MAPT (0.44) | PTGESALOX5KDM4EALDH1A1TUBB4A | |
| SCHEMBL7004935 | 0.76 | MAPT (0.44) | PTGESALOX5KDM4EALDH1A1CYP1A2 | |
| SCHEMBL7002629 | 0.75 | GABRA1 (0.44) | PTGESALOX5KDM4EALDH1A1CYP1A2 | |
| SCHEMBL7006235 | 0.75 | ALDH1A1 (0.43) | PTGESALOX5KDM4EALDH1A1CYP1A2 | |
| SCHEMBL7003912 | 0.72 | LTB4R2 (0.43) | PTGESKDM4EALDH1A1TUBB4ATUBB | |
| SCHEMBL7006743 | 0.72 | TUBB4A (0.44) | PTGESALOX5KDM4EALDH1A1CYP1A2 | |
| SCHEMBL9023953 | 0.70 | HSD17B10 (0.49) | KDM4EALDH1A1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL6859416 | 0.69 | EDNRB (0.45) | FBP1KDM4EALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL7003117 | 0.69 | FBP1 (0.50) | FBP1KDM4EALDH1A1TUBB4ATUBB | |
| SCHEMBL28455858 | 0.69 | FBP1 (0.69) | FBP1ALDH1A1MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1341761-A1 | SUBSTITUTED INDOLES, PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH INDOLES AND THEIR USE AS PPAR-$g(g) BINDING AGENTS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-09-10 | — | — | EP | disclosed |
| WO-2002030895-A1 | SUBSTITUTED INDOLES, PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH INDOLES AND THEIR USE AS PPAR-η BINDING AGENTS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-04-18 | — | — | WO | disclosed |