Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.43 |
| ▸ | HPGD | P15428 | 7/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.41 |
| ▸ | TUBB | P07437 | 2/20 | 0.41 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.41 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.41 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.41 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7002629 | 0.88 | GABRA1 (0.44) | ALDH1A1HPGDKDM4EKMT2AMAPT | |
| SCHEMBL7003912 | 0.87 | LTB4R2 (0.43) | ALDH1A1HPGDKDM4EKMT2AMAPT | |
| SCHEMBL7004935 | 0.85 | MAPT (0.44) | ALDH1A1HPGDKDM4EKMT2AMAPT | |
| SCHEMBL9023953 | 0.85 | HSD17B10 (0.49) | ALDH1A1HPGDKDM4EKMT2AMAPT | |
| SCHEMBL7006743 | 0.81 | TUBB4A (0.44) | ALDH1A1HPGDKDM4EKMT2AMAPT | |
| SCHEMBL7004612 | 0.78 | MAPT (0.44) | ALDH1A1HPGDKDM4EKMT2AMAPT | |
| SCHEMBL7005935 | 0.77 | ALOX5 (0.45) | ALDH1A1HPGDKDM4EKMT2AMAPT | |
| SCHEMBL9023820 | 0.77 | MAPT (0.46) | ALDH1A1HPGDKDM4EKMT2AMAPT | |
| SCHEMBL7003114 | 0.75 | FBP1 (0.45) | ALDH1A1HPGDKDM4EKMT2AMAPT | |
| SCHEMBL7005705 | 0.74 | MAPT (0.49) | HPGDKDM4EKMT2AMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1341761-A1 | SUBSTITUTED INDOLES, PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH INDOLES AND THEIR USE AS PPAR-$g(g) BINDING AGENTS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-09-10 | — | — | EP | disclosed |
| WO-2002030895-A1 | SUBSTITUTED INDOLES, PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH INDOLES AND THEIR USE AS PPAR-η BINDING AGENTS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-04-18 | — | — | WO | disclosed |