Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | PDE2A | O00408 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.38 |
| ▸ | CDK4 | P11802 | 1/20 | 0.38 |
| ▸ | PRKACA | P17612 | 1/20 | 0.38 |
| ▸ | PRKACG | P22612 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7002931 | 0.88 | KDM4E (0.46) | HTR2AHTR2CPTPN1MTNR1AMTNR1B | |
| SCHEMBL7005436 | 0.80 | MAPT (0.38) | HTR2AHTR2CALDH1A1MEN1KMT2A | |
| SCHEMBL7006729 | 0.79 | ALOX5 (0.48) | CA2MTNR1AMEN1KMT2AHTR7 | |
| SCHEMBL7006296 | 0.78 | TP53 (0.38) | HTR2AHTR2CMEN1KMT2AHTR7 | |
| SCHEMBL7006877 | 0.78 | HTR3E (0.37) | HTR2AHTR2CALDH1A1MEN1KMT2A | |
| SCHEMBL7006177 | 0.78 | DAO (0.36) | HTR2AHTR2CALDH1A1MEN1KMT2A | |
| SCHEMBL7004919 | 0.76 | MEN1 (0.42) | CA2HTR2AHTR2CMTNR1AMTNR1B | |
| SCHEMBL7004254 | 0.76 | DAO (0.46) | ALDH1A1MEN1KMT2AMAPK1 | |
| SCHEMBL7007358 | 0.75 | CREBBP (0.39) | ALDH1A1 | |
| SCHEMBL7002522 | 0.74 | NQO2 (0.42) | ALDH1A1PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1200439-B1 | 1,2-DIHYDRO-1-OXO-PARAZINO(1,2-A) INDOLE DERIVATIVES | NOVUSPHARMA SPA (IT) | 2003-06-25 | — | — | EP | disclosed |