Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.37 |
| ▸ | HTR3B | O95264 | 2/20 | 0.37 |
| ▸ | HTR3A | P46098 | 2/20 | 0.37 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.37 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | DAO | P14920 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CDK4 | P11802 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7005436 | 0.82 | MAPT (0.38) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL7006296 | 0.81 | TP53 (0.38) | HTR7HTR2CHTR2ACDK4CCND1 | |
| SCHEMBL7003383 | 0.81 | TDP2 (0.39) | RXFP1HTR7DAOHTR2CHTR2A | |
| SCHEMBL7006177 | 0.81 | DAO (0.36) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL7004254 | 0.78 | DAO (0.46) | LMNADAOKDM4EALDH1A1BRD4 | |
| SCHEMBL7007358 | 0.77 | CREBBP (0.39) | KDM4EALDH1A1BRD4CREBBPHPGD | |
| SCHEMBL7002739 | 0.72 | GRIA1 (0.39) | DAOHTR2CHTR2AKDM4EBRD4 | |
| SCHEMBL7006729 | 0.70 | ALOX5 (0.48) | HTR7CDK4CCND1CREBBPCCNE2 | |
| SCHEMBL7009822 | 0.70 | HTR2A (0.43) | ATMLMNADAOHTR2CHTR2A | |
| SCHEMBL9919030 | 0.69 | CDK4 (0.43) | ATMKDM4EALDH1A1CDK4CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1200439-B1 | 1,2-DIHYDRO-1-OXO-PARAZINO(1,2-A) INDOLE DERIVATIVES | NOVUSPHARMA SPA (IT) | 2003-06-25 | — | — | EP | disclosed |