Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 2/20 | 0.36 |
| ▸ | HTR7 | P34969 | 5/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | AHR | P35869 | 1/20 | 0.33 |
| ▸ | TAF1 | P21675 | 1/20 | 0.33 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | CECR2 | Q9BXF3 | 1/20 | 0.33 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | CCND1 | P24385 | 1/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 2/20 | 0.33 |
| ▸ | PTGES | O14684 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7005436 | 0.82 | MAPT (0.38) | BRD4HTR7MEN1KMT2ATAF1 | |
| SCHEMBL7003383 | 0.81 | TDP2 (0.39) | TP53BRD4HTR7CREBBPHRH4 | |
| SCHEMBL7006177 | 0.81 | DAO (0.36) | BRD4MEN1KMT2ATAF1BRPF1 | |
| SCHEMBL7006877 | 0.81 | HTR3E (0.37) | TP53BRD4HTR7MEN1KMT2A | |
| SCHEMBL7004254 | 0.78 | DAO (0.46) | TP53BRD4MEN1KMT2ATAF1 | |
| SCHEMBL7007358 | 0.77 | CREBBP (0.39) | BRD4CREBBPMAPT | |
| SCHEMBL7006748 | 0.72 | BRD4 (0.45) | TP53BRD4AHRGSK3B | |
| SCHEMBL7006729 | 0.70 | ALOX5 (0.48) | HTR7MEN1KMT2ACREBBPCCNE2 | |
| SCHEMBL9919029 | 0.69 | PSMB1 (0.46) | BRD4MEN1KMT2ATAF1BRPF1 | |
| SCHEMBL7002931 | 0.69 | KDM4E (0.46) | TP53GSK3BHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1200439-B1 | 1,2-DIHYDRO-1-OXO-PARAZINO(1,2-A) INDOLE DERIVATIVES | NOVUSPHARMA SPA (IT) | 2003-06-25 | — | — | EP | disclosed |