SCHEMBL7003658

SCHEMBL7003658

Cc1cc(O)ccc1Nc1ccccc1Cl

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.55
HSD17B10 Q99714 2/20 0.55
GAA P10253 2/20 0.55
MAPT P10636 2/20 0.55
ALOX15 P16050 2/20 0.55
ALDH1A1 P00352 1/20 0.55
LMNA P02545 1/20 0.55
CASP1 P29466 1/20 0.55
CASP7 P55210 1/20 0.55
RUNX1 Q01196 1/20 0.55
CBFB Q13951 1/20 0.55
TNIK Q9UKE5 4/20 0.47
MEN1 O00255 2/20 0.43
KMT2A Q03164 2/20 0.43
ATM Q13315 1/20 0.43
RAPGEF4 Q8WZA2 1/20 0.42
TRPV1 Q8NER1 1/20 0.42
MAPK14 Q16539 1/20 0.42
CXCL8 P10145 1/20 0.41
TSHR P16473 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11341031 0.85 GAA (0.62) KDM4EHSD17B10GAAMAPTALOX15
SCHEMBL7644039 0.83 GAA (0.61) KDM4EHSD17B10GAAMAPTALOX15
SCHEMBL7002965 0.79 MAPT (0.55) KDM4EHSD17B10GAAMAPTALOX15
Acetic Acid SCHEMBL9524953 0.78 CAMK2A (0.59) KDM4EHSD17B10GAAMAPTALOX15
SCHEMBL7002680 0.77 GAA (0.64) GAAMAPTALDH1A1LMNAMEN1
SCHEMBL11019768 0.77 MAPT (0.53) KDM4EHSD17B10GAAMAPTALOX15
SCHEMBL10654473 0.77 ALDH1A1 (0.56) KDM4EHSD17B10GAAMAPTALOX15
SCHEMBL7003152 0.77 GAA (0.60) KDM4EHSD17B10GAAMAPTALOX15
SCHEMBL7003942 0.76 RAPGEF4 (0.64) KDM4EHSD17B10GAAMAPTALOX15
SCHEMBL10938235 0.76 AKR1C3 (0.56) KDM4EHSD17B10GAAMAPTALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6635602-B1 Heat sensitive and pressure sensitive recording material; synthesised directly by the reaction of two derivatives of amino phenols, phthalic anhydrides, keto acids and/or diphenylamines with a phenol derivative CIBA SPECIALTY CHEMICALS CORPORATION 2003-10-21 US disclosed
US-6566302-B1 For use in heat sensitive and pressure sensitive recording materials CIBA SPECIALTY CHEMICALS CORPORATION 2003-05-20 US disclosed
EP-1107972-B1 PREPARATION PROCESS FOR MANUFACTURE AND PURIFICATION OF MIXTURES OF FLUORAN COMPOUNDS AND RECORDING MATERIAL COMPRISING SAID MIXTURES OF FLUORAN CIBA SC HOLDING AG (CH) 2003-01-02 EP disclosed
EP-1115579-B1 MONOPHASE SOLID SOLUTIONS COMPRISING A PLURALITY OF COLOUR FORMER COMPOUNDS AND PROCESS FOR THEIR PREPARATION CIBA SC HOLDING AG (CH) 2002-11-20 EP disclosed
EP-1115579-A1 MONOPHASE SOLID SOLUTIONS COMPRISING A PLURALITY OF COLOUR FORMER COMPOUNDS AND PROCESS FOR THEIR PREPARATION Ciba SC Holding AG (CH) 2001-07-18 EP disclosed
WO-2000026037-A1 HEAT SENSITIVE RECORDING MATERIAL CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2000-05-11 WO disclosed
WO-2000012318-A1 MONOPHASE SOLID SOLUTIONS COMPRISING A PLURALITY OF COLOUR FORMER COMPOUNDS AND PROCESS FOR THEIR PREPARATION CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2000-03-09 WO disclosed