SCHEMBL7708360

SCHEMBL7708360

CCCC1Sc2ccc(C(F)(F)F)cc2N=C1N

nearest known ligand 0.40

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ADAMTS5 Q9UNA0 1/20 0.40
NOS3 P29474 1/20 0.39
NOS1 P29475 1/20 0.39
NOS2 P35228 1/20 0.39
PTPN5 P54829 1/20 0.36
LMNA P02545 2/20 0.36
MAPT P10636 4/20 0.35
TP53 P04637 2/20 0.34
SMN1; SMN2 Q16637 2/20 0.34
ATM Q13315 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
CTSD P07339 5/20 0.33
HTT P42858 1/20 0.32
EPHX2 P34913 1/20 0.32
SCN4A P35499 1/20 0.32
CYBB P04839 1/20 0.31
NOX3 Q9HBY0 1/20 0.31
NOX4 Q9NPH5 1/20 0.31
NOX1 Q9Y5S8 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7708239 0.89 NOS3 (0.40) ADAMTS5NOS3NOS1NOS2PTPN5
SCHEMBL7713419 0.79 NOS3 (0.43) NOS3NOS1NOS2PTPN5MAPT
SCHEMBL7000029 0.71 LMNA (0.45) ADAMTS5PTPN5LMNAMAPTTP53
SCHEMBL7004061 0.71 LMNA (0.58) ADAMTS5LMNAMAPTTP53SMN1; SMN2
SCHEMBL5670586 0.63 KDM4E (0.38) NOS3NOS1NOS2MAPTTP53
SCHEMBL6999115 0.62 LMNA (0.47) PTPN5LMNAMAPTTP53SMN1; SMN2
SCHEMBL6993134 0.62 LMNA (0.60) ADAMTS5LMNAMAPTTP53SMN1; SMN2
SCHEMBL7708028 0.62 NOS3 (0.43) NOS3NOS1NOS2CTSDEPHX2
SCHEMBL10857604 0.61 TLR8 (0.38) ADAMTS5MAPT
SCHEMBL8523594 0.60 LMNA (0.50) ADAMTS5LMNAMAPTTP53SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6365736-B1 TREATMENT OF NERVOUS SYSTEM DISORDERS, CARDIOVASCULAR DISORDERS AND FOR ACTIVITY AS NO-SYNTHASES (NOS) INHIBITORS. SCHERING AKTIENGESELLSCHAFT (DE) 2002-04-02 US disclosed