Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.61 |
| ▸ | USP2 | O75604 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.61 |
| ▸ | HPGD | P15428 | 6/20 | 0.61 |
| ▸ | AIP | O00170 | 1/20 | 0.51 |
| ▸ | SGTA | O43765 | 1/20 | 0.51 |
| ▸ | TOMM70 | O94826 | 1/20 | 0.51 |
| ▸ | STIP1 | P31948 | 1/20 | 0.51 |
| ▸ | PPP5C | P53041 | 1/20 | 0.51 |
| ▸ | FKBP4 | Q02790 | 1/20 | 0.51 |
| ▸ | PPID | Q08752 | 1/20 | 0.51 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.51 |
| ▸ | FKBP8 | Q14318 | 1/20 | 0.51 |
| ▸ | TOMM34 | Q15785 | 1/20 | 0.51 |
| ▸ | DNAJC7 | Q99615 | 1/20 | 0.51 |
| ▸ | AIPL1 | Q9NZN9 | 1/20 | 0.51 |
| ▸ | STUB1 | Q9UNE7 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 5/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14305225 | 0.78 | ALDH1A1 (0.63) | MEN1KMT2AUSP2ALDH1A1HPGD | |
| SCHEMBL23657647 | 0.74 | MEN1 (0.58) | MEN1KMT2AUSP2ALDH1A1HPGD | |
| SCHEMBL289795 | 0.73 | THRB (0.69) | MEN1KMT2AALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL1687071 | 0.73 | THRB (0.73) | MEN1KMT2AALDH1A1RAB9AHSD17B10 | |
| SCHEMBL14462124 | 0.72 | THRB (0.63) | MEN1KMT2AALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL13614959 | 0.72 | THRB (0.67) | MEN1KMT2AALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL7408732 | 0.71 | THRB (0.71) | MEN1KMT2ARAB9ASMN1; SMN2NPC1 | |
| SCHEMBL3864600 | 0.71 | THRB (0.75) | MEN1KMT2ARAB9ASMN1; SMN2NPC1 | |
| SCHEMBL12768285 | 0.71 | RAB9A (0.61) | MEN1KMT2AUSP2ALDH1A1HPGD | |
| SCHEMBL7003055 | 0.70 | AIP (0.74) | MEN1KMT2AALDH1A1HPGDAIP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1294707-A2 | THIOPHENE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2003-03-26 | — | — | EP | claimed |
| US-6414013-B1 | KINASE INHIBITORS; ANTICANCER AGENTS | PHARMACIA & UPJOHN S.P.A. (IT) | 2002-07-02 | — | — | US | claimed |
| WO-2001098290-A2 | THIOPHENE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA S.P.A. (IT) | 2001-12-27 | — | — | WO | claimed |