Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 7/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 4/20 | 0.39 |
| ▸ | PTGER3 | P43115 | 4/20 | 0.39 |
| ▸ | PTGER2 | P43116 | 4/20 | 0.39 |
| ▸ | RXRA | P19793 | 1/20 | 0.37 |
| ▸ | RXRB | P28702 | 1/20 | 0.37 |
| ▸ | RXRG | P48443 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | SMPD1 | P17405 | 2/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7003666 | 0.89 | PPARG (0.41) | PTGER1PTGER4PTGER3PTGER2KDM4E | |
| SCHEMBL7560366 | 0.85 | PTGER1 (0.37) | PTGER1PTGER4PTGER3PTGER2ABCB1 | |
| SCHEMBL7003191 | 0.83 | HPGD (0.41) | PTGER1PTGER4PTGER3PTGER2MCL1 | |
| SCHEMBL7004236 | 0.81 | MMP2 (0.43) | PTGER1MRGPRX4 | |
| SCHEMBL7556080 | 0.80 | CRHBP (0.43) | PTGER1PTGER4PTGER3PTGER2MCL1 | |
| SCHEMBL7595947 | 0.71 | DPP4 (0.39) | — | |
| SCHEMBL1381646 | 0.70 | HK2 (0.40) | — | |
| SCHEMBL7560338 | 0.68 | CRHBP (0.43) | PTGER1MCL1KDM4EMRGPRX4 | |
| SCHEMBL5231509 | 0.67 | DPP4 (0.59) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5234388 | 0.67 | DPP4 (0.58) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1355886-A1 | FUSED HETEROCYCLIC COMPOUNDS | Takeda Chemical Industries, Ltd. (JP) | 2003-10-29 | — | — | EP | disclosed |
| WO-2002062764-A9 | FUSED HETEROCYCLIC COMPOUNDS | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2002-10-10 | — | — | WO | disclosed |
| WO-2002062764-A1 | FUSED HETEROCYCLIC COMPOUNDS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2002-08-15 | — | — | WO | disclosed |