Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dihydrofolic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | DHFR | P00374 | 3/20 | 0.42 |
| ▸ | GART | P22102 | 3/20 | 0.42 |
| ▸ | ATIC | P31939 | 2/20 | 0.42 |
| ▸ | SOST | Q9BQB4 | 1/20 | 0.42 |
| ▸ | MTHFD1 | P11586 | 2/20 | 0.40 |
| ▸ | MTHFD2 | P13995 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dihydrofolic Acid SCHEMBL7522026 | 0.94 | TYMS (0.66) | TYMSKDM4EMEN1ALDH1A1POLB | |
| Dihydrofolic Acid SCHEMBL1880562 | 0.86 | TYMS (0.78) | TYMSKDM4EMEN1ALDH1A1POLB | |
| Folic Acid SCHEMBL8897352 | 0.82 | TYMS (0.80) | TYMSKDM4EMEN1ALDH1A1POLB | |
| Folic Acid SCHEMBL1427313 | 0.79 | TYMS (0.95) | TYMSKDM4EMEN1ALDH1A1POLB | |
| Dihydrofolic Acid SCHEMBL12136386 | 0.78 | SOST (0.61) | TYMSKDM4EMEN1ALDH1A1POLB | |
| Folic Acid SCHEMBL38662929 | 0.78 | TYMS (0.97) | TYMSKDM4EMEN1ALDH1A1POLB | |
| Dihydrofolic Acid SCHEMBL27589172 | 0.78 | SOST (0.61) | TYMSKDM4EMEN1ALDH1A1POLB | |
| Dihydrofolic Acid SCHEMBL8281 | 0.78 | SOST (0.61) | TYMSKDM4EMEN1ALDH1A1POLB | |
| Dihydrofolic Acid SCHEMBL8282 | 0.78 | SOST (0.61) | TYMSKDM4EMEN1ALDH1A1POLB | |
| Dihydrofolic Acid SCHEMBL27415499 | 0.77 | SOST (0.60) | TYMSKDM4EMEN1ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268774-A2 | IDENTIFICATION OF ESSENTIAL GENES IN PROKARYOTES | Elitra Pharmaceuticals, Inc. (US) | 2003-01-02 | — | — | EP | disclosed |
| WO-2002077183-A2 | IDENTIFICATION OF ESSENTIAL GENES IN MICROORGANISMS | ELITRA PHARMACEUTICALS, INC. (US) | 2002-10-03 | — | — | WO | disclosed |
| WO-2001070955-A2 | IDENTIFICATION OF ESSENTIAL GENES IN PROKARYOTES | ELITRA PHARMACEUTICALS, INC. (US) | 2001-09-27 | — | — | WO | disclosed |