Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 2/20 | 0.78 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.78 |
| ▸ | MEN1 | O00255 | 1/20 | 0.78 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.78 |
| ▸ | POLB | P06746 | 1/20 | 0.78 |
| ▸ | GAA | P10253 | 1/20 | 0.78 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.78 |
| ▸ | HPGD | P15428 | 1/20 | 0.78 |
| ▸ | TSHR | P16473 | 1/20 | 0.78 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.78 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.78 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.78 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.78 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.59 |
| ▸ | DHFR | P00374 | 3/20 | 0.55 |
| ▸ | GART | P22102 | 3/20 | 0.55 |
| ▸ | ATIC | P31939 | 2/20 | 0.55 |
| ▸ | SOST | Q9BQB4 | 1/20 | 0.52 |
| ▸ | MTHFD1 | P11586 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dihydrofolic Acid SCHEMBL7522026 | 0.92 | TYMS (0.66) | TYMSKDM4EMEN1ALDH1A1POLB | |
| Dihydrofolic Acid SCHEMBL8281 | 0.90 | SOST (0.61) | TYMSKDM4EMEN1ALDH1A1POLB | |
| Dihydrofolic Acid SCHEMBL27589172 | 0.90 | SOST (0.61) | TYMSKDM4EMEN1ALDH1A1POLB | |
| Dihydrofolic Acid SCHEMBL8282 | 0.90 | SOST (0.61) | TYMSKDM4EMEN1ALDH1A1POLB | |
| Folic Acid SCHEMBL38662929 | 0.90 | TYMS (0.97) | TYMSKDM4EMEN1ALDH1A1POLB | |
| Dihydrofolic Acid SCHEMBL12136386 | 0.90 | SOST (0.61) | TYMSKDM4EMEN1ALDH1A1POLB | |
| Dihydrofolic Acid SCHEMBL27415499 | 0.89 | SOST (0.60) | TYMSKDM4EMEN1ALDH1A1POLB | |
| Dihydrofolic Acid SCHEMBL27779274 | 0.89 | SOST (0.60) | TYMSKDM4EMEN1ALDH1A1POLB | |
| Folic Acid SCHEMBL5365896 | 0.89 | TYMS (0.97) | TYMSKDM4EMEN1ALDH1A1POLB | |
| Folic Acid SCHEMBL332170 | 0.89 | TYMS (1.00) | TYMSKDM4EMEN1ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7947662-B2 | Folates, compositions and uses thereof | GNOSIS S.P.A. (IT) | 2011-05-24 | — | — | US | claimed |
| US-20160207925-A1 | L-METHYLFOLATE SALT PREPARATIONS, MEDICAMENTS, AND NUTRITIONAL SUPPLEMENTS COMPRISING SUCH SALTS THEREOF | FRACCHIA GIANNI (AU) | 2016-07-21 | — | — | US | disclosed |
| EP-2245032-B1 | FOLATES, COMPOSITIONS AND USES THEREOF | GNOSIS SPA (IT) | 2015-03-25 | — | — | EP | disclosed |
| EP-2245032-A1 | FOLATES, COMPOSITIONS AND USES THEREOF | Gnosis S.p.A. (IT) | 2010-11-03 | — | — | EP | disclosed |
| WO-2009103334-A1 | FOLATES, COMPOSITIONS AND USES THEREOF | GNOSIS S.P.A. (IT) | 2009-08-27 | — | — | WO | disclosed |
| US-5624564-A | Process for dehydration and concentration of sewage sludge | BLUM HOLGER (DE) | 1997-04-29 | — | — | US | disclosed |
| US-4956092-A | Method for concentrating/dehydrating of sewage sludge | BLUM HOLGER (DE) | 1990-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160207925-A1 | L-METHYLFOLATE SALT PREPARATIONS, MEDICAMENTS, AND NUTRITIONAL SUPPLEMENTS COMPRISING SUCH SALTS THEREOF | DHFR, MTHFD1, BHMT2 | TYMS 80/4885KDM4E 455/4885MEN1 775/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.