Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.60 |
| ▸ | TP53 | P04637 | 5/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | TSPO | P30536 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7002472 | 0.87 | TSPO (0.56) | MAPTTP53KDM4EALDH1A1POLB | |
| SCHEMBL7626412 | 0.87 | MAPT (0.55) | MAPTTP53KDM4EALDH1A1POLB | |
| SCHEMBL3920705 | 0.86 | TSPO (0.54) | MAPTTP53KDM4EALDH1A1POLB | |
| SCHEMBL7626011 | 0.82 | TSPO (0.64) | MAPTTP53TSPOSMN1; SMN2 | |
| SCHEMBL7626419 | 0.80 | TSPO (0.58) | MAPTTP53ALDH1A1TSPOSMN1; SMN2 | |
| SCHEMBL7003823 | 0.80 | TSPO (0.71) | MAPTTP53KDM4EALDH1A1POLB | |
| SCHEMBL7001447 | 0.79 | TSPO (0.62) | MAPTTP53KDM4EALDH1A1POLB | |
| SCHEMBL7003506 | 0.79 | TSPO (0.59) | MAPTTP53POLBTSPO | |
| SCHEMBL3923071 | 0.78 | TSPO (0.55) | MAPTTP53KDM4EALDH1A1POLB | |
| SCHEMBL5673626 | 0.77 | MAPT (0.44) | MAPTTP53KDM4EALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1149101-B1 | 4-OXO-3,5-DIHYDRO-4$i(H)-PYRIDAZINO 4,5-$i(b)]INDOLE-1-CARBOXAMIDE DERIVATIVES, PREPARATION AND THERAPEUTIC USE | SANOFI SYNTHELABO (FR) | 2003-04-09 | — | — | EP | disclosed |
| US-6451795-B1 | CENTRAL NEURODEGENERATIVE DISEASES | SANOFI-SYNTHELABO (FR) | 2002-09-17 | — | — | US | disclosed |