Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSPO | P30536 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 6/20 | 0.52 |
| ▸ | POLB | P06746 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.47 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7001447 | 0.92 | TSPO (0.62) | TSPOTP53POLBMAPTKDM4E | |
| SCHEMBL5702445 | 0.90 | TSPO (0.67) | TSPOTP53POLBMAPT | |
| SCHEMBL7626412 | 0.88 | MAPT (0.55) | TSPOTP53POLBMAPTKDM4E | |
| SCHEMBL7005121 | 0.87 | MAPT (0.60) | TSPOTP53POLBMAPTKDM4E | |
| SCHEMBL7001998 | 0.87 | TSPO (0.57) | TSPOTP53POLBMAPTKDM4E | |
| SCHEMBL7498096 | 0.81 | TSPO (0.56) | TSPOTP53POLBMAPTKDM4E | |
| SCHEMBL7626011 | 0.81 | TSPO (0.64) | TSPOTP53MAPT | |
| SCHEMBL7626419 | 0.81 | TSPO (0.58) | TSPOTP53MAPTALDH1A1HPGD | |
| SCHEMBL7003823 | 0.80 | TSPO (0.71) | TSPOTP53POLBMAPTKDM4E | |
| SCHEMBL7631555 | 0.80 | TSPO (0.65) | TSPOMAPTKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1149101-B1 | 4-OXO-3,5-DIHYDRO-4$i(H)-PYRIDAZINO 4,5-$i(b)]INDOLE-1-CARBOXAMIDE DERIVATIVES, PREPARATION AND THERAPEUTIC USE | SANOFI SYNTHELABO (FR) | 2003-04-09 | — | — | EP | disclosed |